Download PDF
Synlett 1994; 1994(7): 501-503
DOI: 10.1055/s-1994-23148
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Highly Enantioselective Hydrogenation of α,(β-Unsaturated Carboxylic Acids Catalyzed by H8-BINAP-Ru(II) Complexes

Xiaoyong Zhang* , Toshitsugi Uemura, Kazuhiko Matsumura, Noboru Sayo, Hidenori Kumobayashi, Hidemasa Takaya
  • *Division of Material Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto 606-01, Japan
Further Information

Publication History

Publication Date:
18 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Asymmetric hydrogenation of a series of α,β-unsaturated carboxylic acids catalyzed by the H8-BINAP-Ru(II) complexes, Ru(OCOCH3)2[(S)-H8-binap] and [RuI((R)-H8-binap)(p-cymene)]I [H8-BINAP = 2,2′-bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′- octahydro-1,1′-binaphthyl], affords the corresponding saturated carboxylic acids in excellent enantioselectivities (86-97%). This reaction has also been applied to the synthesis of (S)-ibuprofen in 97% ee.

      >