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Synlett 1996; 1996(5): 444
DOI: 10.1055/s-1996-5462
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Highly Efficient Synthesis of (Z)-α-Fluoro-β-thio Acrylaldehydes by Triethylamine Induced Reactions of Polyfluoro-1-propenyl Benzenesulfonates with Thiols

Kazumasa Funabiki* , Chieko Ohtake, Hiroshige Muramatsu, Masaki Matsui, Katsuyoshi Shibata
  • *Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu, 501-11, Japan
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Publication Date:
31 December 2000 (online)

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2,3,3-Trifluoro-1-propenyl p-methyl- or p-chlorobenzenesulfonate, (1) readily available from 2,2,3,3-tetrafluoropropanol, reacted smoothly with various thiols in the presence of triethylamine at ambient temperature for 3 h to afford the corresponding (Z)-α-fluoro-β-thio acrylaldehydes (2) in good yields.

Polyfluoro-1-propenyl p-Methyl- or p-Chlorobenzenesulfonate - (Z)-α-Fluoro-β-thio Acrylaldehydes

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