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Synlett 1996; 1996(12): 1189-1190
DOI: 10.1055/s-1996-5703
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Convenient Asymmetric Synthesis of (1R,3R)-(+)- and (1S,3S)-(-)-1,3-Diphenylpropane-1,3-diols

Gregory H. P. Roos* , A. Richard Donovan
  • *Chemistry Department, Murdoch University, Murdoch 6150, Western Australia, Fax +61(9)3101711, e-mail roos@chem.murdoch.edu.au
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Publication History

Publication Date:
31 December 2000 (online)

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Kinetic resolution via a Sharpless epoxidation serves as the key step to provide the useful C2 chiral auxiliaries (R,R)- and (S,S)-1,3-diphenylpropane-1,3-diols, in good yield and high enantiomeric purity from the commercially available 1,3-diphenylprop-1-en-3-one.

Sharpless epoxidation - Kinetic resolution - Asymmetric synthesis - C2 symmetric 1,3-diols - 1,3-Diphenylpropan-1,3-diols

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