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Synlett 1996; 1996(12): 1184-1186
DOI: 10.1055/s-1996-5711
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Facile Synthesis of Functionalised β-Lactones; Novel Cyclisations of Chromium Carbene Complexes with Propargylic Alcohols

Joseph P. A. Harrity, Nicola M. Heron, William J. Kerr* , Sharon McKendry, David Middlemiss, James S. Scott
  • *Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, Glasgow, G1 1XL, Scotland, U.K., Fax: (0141)-552-5664, E-mail: cbas69@strath.ac.uk
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Publication History

Publication Date:
31 December 2000 (online)

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Thermal reactions of readily available chromium carbene complexes and propargylic alcohols in the presence of acetic anhydride and triethylamine provide new and efficient routes into functionalised β-lactones; this unprecedented Cr-mediated cyclisation process has been shown to be possible with a series of (3y-1y) propargylic alcohols.

Chromium carbene complexes - β-Lactones - Propargylic alcohols - Lactonisation - Vinyl ketene

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