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Synthesis 1997; 1997(5): 563-566
DOI: 10.1055/s-1997-1230
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Palladium(0)-Catalyzed Preparation of 4-Arylpyrazoles

José Elguero1 , Carlos Jaramillo2 , Carmen Pardo3
  • 1Instituto de Química Médica, CSIC, c/Juan de la Cierva 3, E-28006 Madrid, Spain
  • 2Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense, E-28040 Madrid, Spain
  • 3Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense, E-28040 Madrid, Spain, Fax +34(1)3944103; E-mail chpardo@eucmax.sim.ucm.es
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Publication Date:
31 December 2000 (online)

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A general method for the palladium(0)-catalyzed preparation of 4-arylpyrazoles 2, by coupling of either 4-halopyrazoles 3 with arylstannanes 4 or 4-tributylstannyl-1-tritylpyrazole 5 with aryl iodides 6, is reported. Deprotection of trityl and/or methyl groups in compounds 2 led to N-unsubstituted 4-arylpyrazoles 1.

4-arylpyrazoles - 4-stannylpyrazoles - Pd(0) cross-coupling

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