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Synlett 1998; 1998(3): 310-312
DOI: 10.1055/s-1998-1634
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Regioselective Bromomethylation of 1,2-Dialkylbenzenes

Nupur Garg* , T. Randall Lee
  • *Department of Chemistry, University of Houston, Houston, TX 77204-5641, USA; Fax (713)-7 43-27 26; E-mail: trlee@uh.edu
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Publication History

Publication Date:
31 December 2000 (online)

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This paper describes a systematic exploration of the regioselective bromomethylation of 1,2-dialkylbenzenes as a function of the reaction temperature and the chain length of the alkyl groups. At both 80 and 110 °C, bromomethyl groups can be introduced into the 4 and 5 positions of 1,2-dialkylbenzenes with high selectivity when the alkyl chains consist of two or more carbon atoms.

regioselective - aromatic - bromomethylation - 1,2-dialkylbenzenes - 1,2,4,5-tetrasubstitution

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