Anästhesiol Intensivmed Notfallmed Schmerzther 1999; 34(4): 204-213
DOI: 10.1055/s-1999-10833
ORIGINALIA
Georg Thieme Verlag Stuttgart · New York

Prophylaxe des geburtshilflichen Säureaspirationssyndroms in der Bundesrepublik Deutschland 1997

Eine Bestandsaufnahme anhand der Ergebnisse einer bundesweiten UmfrageProphylactic Measures Against Obstetric Acid Aspiration Syndrome in the Federal Republic of Germany 1997. A Review Based on the Results of a Federal Survey. H. Schneck,  B.  v. Hundelshausen,  R. Wagner,   M. Scheller,  E. Kochs
  • Institut für Anaesthesiologie der Technischen Universität München, Klinikum rechts der Isar (Direktor: Univ.-Prof. Dr. E. Kochs)
Further Information

Publication History

Publication Date:
31 December 1999 (online)

Zusammenfassung.

In einer Fragebogenaktion wurden die LeiterInnen der Anästhesieabteilungen von 1061 deutschen Kliniken mit geburtshilflicher Abteilung angeschrieben und nach dem routinemäßigen Vorgehen zur Prophylaxe des Säureaspirationssyndroms (SAS) bei Schwangeren und bei geburtshilflichen Eingriffen befragt (Methoden zur Verhinderung einer Aspiration durch Lagerung, Sellick-Handgriff, Verringerung des Mageninhalts bzw. zur Abmilderung der Konsequenzen einer Aspiration auf medikamentösem Wege). Bei hohem Rücklauf (82 %) wurden dabei fast 700 000 Geburten einschließlich nahezu 115 000 Sectiones erfaßt. Vor der Anästhesie bei Schwangeren wird in 36 Prozent routinemäßig eine Prophylaxe des SAS durchgeführt, meist ab etwa der 20. Schwangerschaftswoche. Prophylaxemaßnahmen bei vaginaler Geburt sind selten (7 %). Bei elektiver (dringlicher) Sectio führen vor Allgemeinanästhesie 93 % (94 %) der Kliniken, vor Regionalanästhesie 52 % (52 %) eine SAS-Prophylaxe durch. Bei anderen geburtshilflichen Eingriffen (z. B. Nachräumung) werden regelmäßig Maßnahmen der SAS-Prophylaxe vor Allgemeinanästhesie in 77 %, vor Regionalanästhesie in 23 % getroffen.

A survey of all German hospitals providing obstetric anesthesia was performed in 1997 (n = 1061, recovery rate 82 %; comprising about 700 000 deliveries and 115 000 cesareans, resp.) concerning the routine prophylactic measures for acid aspiration syndrome (AAS) in pregnant patients and before obstetric procedures (i. e., prevention of aspiration by positioning, Sellick's manoeuvre, reduction of intragastric volume, or reduction of gastric content acidity). In pregnant patients, any prophylaxis of AAS is performed in 36 %. Of the patients expecting delivery in the labour ward, only 7 % receive pharmacological AAS treatment. Before scheduled (urgent, non-emergency) cesarean section in general anesthesia, 93 % (94 %) of patients receive prophylactic treatment, either pharmacological or non-pharmacological. Before regional anesthesia, the corresponding numbers are 52 % for both scheduled or urgent CS.

Literatur

  • 1 Søreide E, Holst-Larsen H, Steen PA. Acid aspiration syndrome prophylaxis in gynaecological and obstetric patients.  Acta Anaesthesiol Scand. 1994;  38 863-868
  • 2 Tordoff SG, Sweeney BP. Acid aspiration prophylaxis in 288 obstetric anaesthetic departments in the United Kingdom.  Anaesthesia. 1990;  45 776-780
  • 3 Benhamou D. French obstetric anaesthetics and acid aspiration prophylaxis.  Europ J Anaesthesiol. 1993;  10 27-32
  • 4 Burgess RW, Crowhurst JA. Acid aspiration prophylaxis in Australian obstetric hospitals - a survey.  Anaesth Intens Care. 1989;  17 492-495
  • 5 Goerig W. Ursprünge des Nüchternheitsgebotes.  Anästhesiol Intensivmed Notfallmed Schmerzther. 1996;  31 245-248
  • 6 Arndt M, Benad G. Die Risiken der Anästhesie bei geburtshilflichen Eingriffen.  Anaesthesiol Reanim. 1994;  19 88-94
  • 7 Macfie AG, Magides AD, Richmond MN, Reilly CS. Gastric emptying in pregnancy.  Br J Anaesth. 1991;  7 54-75
  • 8 Sandhar BK, Elliott RH, Windram J, Rowbotham DJ. Peripartum changes in gastric emptying.  Anaesthesia. 1992;  47 196-198
  • 9 Hardy JF, Lepage Y, Bonneville-Choinard N. Occurence of gastroesophageal reflux on induction of anaesthesia does not correlate with the volume of gastric contents.  Can J Anaesth. 1990;  37 502-508
  • 10 Phillips S, Hutchinson S, Davidson T. Preoperative drinking does not affet gastric content.  Br J Anaesth. 1993;  70 6-9
  • 11 Ngwingtin L, Glomaud D, Hardy F, Phil S. Omeprazole for prophylaxis of acid aspiration in elective surgery.  Anaesthesia. 1990;  45 436-438
  • 12 Vincent RD jr, McNeil TJ, Spaid CL, MacMahon FR, Maxwell SJ, Brenner JS, Schryer VL. Does 360 ml of apple juice ingested before elective surgery worsen gastric volume and acidity in patients given aspiration prophylaxis?.  J Clin Anesth. 1991;  3 285-289
  • 13 Gallagher EG, White M, Ward S, Cottrell J, Mann SG. Prophylaxis against acid aspiration syndrome. Single oral dose of H2-antagonist on the evening before elective surgery.  Anaesthesia. 1988;  43 1011-1014
  • 14 Callander P, Hunphrey D, Brock-Utne JG. the use of gastrozepin as a prophylaxis against pulmonary acid aspiration: a new muscarinic receptor antagonist.  Eur J Anaesthesiol. 1987;  4 149-153
  • 15 Ong BY, Palahniuk RJ, Cumming M. Gastric volume and pH in outpatients.  Can Anaesth Soc J. 1978;  25 36-39
  • 16 Vila P, Espachs P, Echevarria V, Garcia M, Rincon R, Vidal F. Acid aspiration prophylaxis in elective biliary surgey. A comparison of omeprazole and famotidine using manually aided gastric emptying.  Anaesthesia. 1994;  49 909-911
  • 17 Søreide E, Søreide JA, Holst-Larsen H, Steen PA. Studies of gastric content: comparison of two methods.  Br J Anaesth. 1993;  70 360-362
  • 18 Jasson J, Lefevre G, Tallet F, Talafre ML, Legagneux F, Conseiller C. Ingestion de citrate de sodium avant l'anésthesie générale pour césarienne programmée. Effect sur le pH et le volume du contenu gastrique.  Ann Fr Anesth Réanim. 1989;  8 12-18
  • 19 Cohen SE, Barrier G. Does metoclopramide decrease gastric volume in cesarean section patients?.  Anesthesiology. 1983;  59 A403
  • 20 Dewan DM, Floyd HM, Thislewood JM, Bogard TD, Spielman FJ. Sodium citrate pretreatment in elective cesarean seciton patients.  Anesth Analg. 1985;  64 34-37
  • 21 Tryba M, Burkert W, Hüsch M, Zenz M. Wirksamkeit von Cimetidin zur Prophylaxe der Aspirationspneumonie in der Geburtshilfe.  Fortschr Med. 1983;  101 1757-1761
  • 22 Ngwingtin L, Hardy F, Hamer R, Glomaud D. Modification du pH et volume du continue gastrique pendant la grossesse et le travail.  Cah Anesthesiol. 1987;  35 607-609
  • 23 Stuart JC, Kan AF, Rowbottom SJ, Yau G, Gin T. Acid aspiration prophylaxis for emergency cesarean section.  Anaesthesia. 1996;  51 415-421
  • 24 Greene NM, Bannister WK, Cohen B, Keet JE, Mancinelli MJ, Welch ET, Welch HJ. Survey of deaths associated with anesthesia in Connecticut.  Conn Med. 1959;  23 512-521
  • 25 Rout CC, Rocke DA, Gouws E. Intravenous ranitidine reduces the risk of acid aspiration of gastric contents at emergency cesarean section.  Anesth Analg. 1993;  76 156-161
  • 26 Kopp VJ, Mayer DC, Shaheen DJ. Intravenous erythromycin promotes gastric emptying prior to emergency anesthesia.  Anesthesiology. 1997;  87 703-704
  • 27 Wyner J, Cohen SE. Gastric volume in early pregnancy.  Anesthesiology. 1982;  57 209-212
  • 28 Rocke DA, Rout CC, Gouws E. Intravenous administration of the proton pump inhibitor omeprazole reduces the risk of acid aspiration at emergency cesarean section.  Anesth Analg. 1994;  78 1093-1098
  • 29 Salmenpera M, Korttila K, Kalima T. Reduction of the risk of acid pulmonary aspiration in anaesthetized patients after cimetidine premedication.  Acta Anaesthesiol Scand. 1980;  24 25-30
  • 30 Braun GG, Koppert W, Martus P, Schywalsky M, Schmitt H, Mogendorf F, Voigt HJ. Die medikamentöse Prophylaxe des Säure-Aspirations-Syndroms bei nicht elektiver Sectio Caesarea.  Anaesthesiol Reanim. 1994;  19 37-42
  • 31 Solanki DR, Suresh M, Ethridge HC. The effects of intravenous cimetidine and metoclopramide on gastric volume and pH.  Anaesth Analg. 1984;  63 599-602
  • 32 Mendelson CL. The aspiration of stomach contents into the lungs during obstetric anesthesia.  Amer J Obstet Gynecol. 1946;  52 191-205
  • 33 Trepanier CA, Isabel L. Perioperative gastric aspiration increases postoperative nausea and vomiting in outpatients.  Can J Anaesth. 1993;  40 325-328
  • 34 Kristensen MS, Gellet S, Bach AB, Jensen TK. Hemodynamics and arterial oxygen saturation during preoperative emptying of the stomach.  Acta Anaesthesiol Scand. 1991;  35 342-344
  • 35 Hall CC. Aspiration pneumonitis - an obstetric hazard.  J Amer Med Ass. 1940;  114 728-733
  • 36 Teabaut JR. Aspiration of gastric contents. An experimental study.  Amer J Pathol. 1952;  28 51-62
  • 37 Roberts RB, Shirley MA. Reducing the risk of acid aspiration during Cesarean section.  Anesth Analg. 1974;  53 859-868
  • 38 Roberts RB, Shirley MA. Letter: Antacid therapy in obstetrics.  Anesthesiology. 1980;  53 83
  • 39 James CF, Modell JH, Gibbs CP, Kuck EJ, Ruiz BC. Pulmonary aspiration - effects of volume and pH in the rat.  Anesth Analg. 1984;  63 665-668
  • 40 Awe WJ, Fletcher WS, Jacob SW. Pathophysiology of aspiration pneumonitis.  Surgery. 1966;  60 232-239
  • 41 Exarhos ND, Logan WD, Abbott OA. The importance of pH and volume in tracheobronchial aspiration.  Dis Chest. 1965;  47 167-169
  • 42 Raidoo DM, Rocke DA, Brock-Utne JG, Marszalek A, Engelbrecht HE. Critical volume for pulmonary acid aspiration: reappraisal in a primate model.  Brit J Anaesth. 1990;  65 248-250
  • 43 Raidoo DM, Marszalek A, Brock-Utne JG. Acid aspiration in primates (a surprising experimental result).  Anaesth Int Care. 1988;  16 665-668
  • 44 Lahiri SK, Thomas TA, Hodgson RMH. Single-dose antacid therapy for the prevention of Mendelson's syndrome.  Brit J Anaesth. 1973;  45 1143-1146
  • 45 Hett DA, Scott RC, Risdall JE. Lansoprazole in the prophylaxis of acid aspiration during elective surgery.  Brit J Anaesth. 1995;  74 614-615
  • 46 O'Connor Ta, Basak J, Parker S. The effect of three different ranitidine dosage regimens on reducing gastric acidity and volume in ambulatory surgical patients.  Pharmacotherapy. 1995;  15 170-175
  • 47 Bouly A, Nathan N, Feiss P. Comparison of omeprazole with cimetidine for prophylaxis of acid aspiration in elective surgery.  Eur J Anaesthesiol. 1993;  10 209-213
  • 48 Escolano F, Castano J, Lopez R, Bisbe E, Alcon A. Effects of omeprazole, ranitidine, famotidine and placebo on gastric secretion in patients undergoing elective surgery.  Br J Anaesth. 1992;  69 404-406
  • 49 Manchikanti L, Colliver JA, Merrero TC, Roush JR. Assessment of age-related acid aspiration risk factors in pediatric, adult, and geriatric patients.  Anesth Analg. 1985;  64 11-17
  • 50 Stoelting RK. Gastric fluid pH in patients receiving cimetidine.  Anesth Analg. 1978;  57 675-677
  • 51 Phillips S, Hutchinson S, Davidson T. Preoperative drinking does not affect gastric contents.  Brit J Anaesth. 1993;  70 6-9
  • 52 Cameron JL, Zuidema GD. Aspiration pneumonia. Magnitude and frequency of the problem.  J Amer Med Ass. 1972;  219 1194-1196
  • 53 Cohen MM, duncan PG, Pope WDB, Wolkenstein C. A survey of 112 000 anaesthetics at one teaching hospital.  Can Anaesth Soc J. 1986;  33 22-31
  • 54 Warner MA, Warner ME, Weber JG. Clinical significance of pulmonary aspiration during the perioperative period.  Anesthesiology. 1993;  78 56-62
  • 55 Mellin-Olsen J, Fasting S, Gisvold SE. Routine preoperative gastric emptying is seldom indicated. A study of 85 594 anaesthetics with special focus on aspiration pneumonia.  Acta Anaesthesiol Scand. 1996;  40 1184-1188
  • 56 Ellmauer S. Prophylaxe und Therapie des Säure-Aspirationssyndroms.  Anaesthesist. 1987;  36 599-607
  • 57 Hovi-Viander M. Death associated with anaesthesia in Finnland.  Brit J Anaesth. 1980;  52 483-489
  • 58 Hatton F, Tiret L, Maujol L, N'Doye P, Vourc'h G, Desmonts JM, Otteni JC, Scherpereel P. INSERM. Enquête épidémiologique sur les anésthésies. Premiers résultats.  Ann Fr Anesth Réanim. 1983;  2 331-385
  • 59 Tikkanen J, Hovi-Viander M. Death associated with anaesthesia and surgery in Finnland 1986 compared to 1975.  Acta Anaesthesiol Scand. 1995;  39 262-267
  • 60 Olsson GL, Hallen B, Hambraeus-Jonzon K. Aspiration during anaesthesia: A computer-aided study of 185 358 anaesthetics.  Acta Anaesthesiol Scand. 1986;  30 84-92
  • 61 Søreide E, Børnestad E, Steen PA. An audit of perioperative aspiration pneumonitis in gynaecological and obstetric patients.  Acta Anaesthesiol Scand. 1996;  40 14-19
  • 62 Krantz ML, Edwards WL. The incidence of nonfatal aspiration in obstetric patients. Letter.  Anesthesiology. 1973;  39 358
  • 63 Stephens ID. ICU admissions from an obstetrical hospital.  Can J Anaesth. 1991;  38 677-681
  • 64 Dindelli M, La Rosa M, Rossi R, Di Nunno D, Piva L, Pagnoni B, Ferrari A. Incidenza e complicazione della sindroma ab ingestis durante taglio cesareo in anestesia generale.  Ann Ost Ginecol Med Perinat. 1991;  112 376-384
  • 65 La Rosa M, Piva L, Ravanelli A, Dindelli M, Pagnoni B. La sindroma d'aspiratzione in corso di taglio cesareo. Nostra esperienza nel periodo 1980 - 1990.  Minerva Anestesiol. 1992;  58 1213-1220
  • 66 Zucker-Pinchoff B. Obstetric Anesthesia Safety Improvement Study (OASIS): a survey of 320 hospitals.  Anesth Analg. 1997;  84 S415
  • 67 Hawkins JL, Koonin LM, Palmer SK, Gibbs CP. Anesthesia-related deaths during obstetric delivery in the United States, 1979 - 1990.  Anesthesiology. 1997;  86 277-284

Prof. Dr. Hajo Schneck

Institut für Anaesthesiologie der Technischen Universität München

Klinikum rechts der Isar

Ismaninger Straße 22

D-81675 München

    >