Synthesis of N-(Dialkylaminoalkyl)alcohols by Homogeneously Catalyzed Hydrogenolysis of Cyclic N,O-Acetals

Vitali I. Tararov; Renat Kadyrov; Thomas H. Riermeier; Armin Börner

doi:10.1055/s-2002-20039

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Synthesis 2002(3): 0375-0380
DOI: 10.1055/s-2002-20039

PAPER

Synthesis of N-(Dialkylaminoalkyl)alcohols by Homogeneously Catalyzed Hydrogenolysis of Cyclic N,O-Acetals

Vitali I. Tararov*^a, Renat Kadyrov^b, Thomas H. Riermeier^b, Armin Börner*^a
^a Institut für Organische Katalyseforschung an der Universität Rostock e.V., Buchbinderstr. 5/6, 18055 Rostock, Germany
Fax: +49(381)4669324; e-Mail: vitali.tararov@ifok.uni-rostock.de; e-Mail: armin.boerner@ifok.uni-rostock.de;
^b Degussa AG, Projekthaus Katalyse, Geschäftsbereich Creavis, Industriepark Hoechst, Gebäude G 830, 65926 Frankfurt/Main, Germany

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Publication History

Received 6 November 2001
Publication Date:
28 July 2004 (online)

Abstract
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Abstract

The homogeneously catalyzed hydrogenation of 1,3-oxazolidines affording unsymmetrically substituted 2-N-(dialkylamino)ethanols is reported showing for the first time that Rh(I) catalysts based on chelating diphosphines can be advantageous for this reaction.

Key words

hydrogenation - transition metals - catalysis - amino alcohols

References

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Tararov, V. I.; Kadyrov, R.; Riermeier, T. H.;, Börner, A. Adv. Synth. Catal., in press.