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Synthesis 2002(5): 0595-0597
DOI: 10.1055/s-2002-23544
DOI: 10.1055/s-2002-23544
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Raney Nickel-Induced 3-Alkylation of Oxindole with Alcohols and Diols
Further Information
Received
18 December 2001
Publication Date:
02 April 2002 (online)
Publication History
Publication Date:
02 April 2002 (online)
Abstract
New reaction conditions are described, which turn Wenkert’s synthesis of 3-alkyloxindoles (Raney nickel-induced alkylation of oxindole with alcohols) into a reproducible and highly efficient synthetic tool. The method is also extended to the preparation of 3-(ω-hydroxyalkyl)oxindoles.
Key words
alcohols - alkylations - diols - oxindole - Raney nickel
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