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Horm Metab Res 2002; 34(6): 338-340
DOI: 10.1055/s-2002-33263
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Analysis of Glucose Tolerance in Twin Gestations Using an Oral Glucose Load

M.  Ihara 1 , M.  Mitao 1 , H.  Yamasaki 1 , T.  Kodama 1 , T.  Murakami 1 , G.  Hirai 1 , T.  Sugiyama 2 , N.  Toyoda 2
  • 1Department of Obstetrics and Gynecology, Hiroshima City Asa Hospital, Hiroshima, Japan
  • 2Department of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Japan
Further Information

Publication History

Received 3 July 2001

Accepted after Revision 25 February 2002

Publication Date:
12 August 2002 (online)

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Abstract

The effect of twin gestation on carbohydrate metabolism was evaluated using a 75 g oral glucose tolerance test (75 g OGTT). A 75 g OGTT was performed in 63 twin gestations and 3 791 singleton gestations during the third trimester. Plasma glucose concentrations were measured in the pregnant women under fasting conditions as well as 30 min, 1 h, and 2 h after ingestion of glucose (75 g oral load), and serum insulin concentrations were measured in fasting and 30 min post-ingestion samples. Women with twin gestations showed significantly lower plasma glucose concentrations during fasting and 30 min after the glucose load in the samples taken than those with singleton gestations. No significant difference in serum glucose concentrations was found in the other specimens. There were no cases of gestational diabetes mellitus in our study. Although women with twin gestations demonstrated lower plasma glucose concentrations than women with singleton gestations, the difference observed was subtle. We could not find any significant differences in these plasma glucose values as used to define a pathologic OGTT between twin and singleton pregnancies, with the exception of the fasting value.

Key words

75 g Oral Glucose Tolerance Test - Twin Gestation - Singleton Gestation - Gestational Diabetes Mellitus

References

  • 1 Hamada T, Tetsunou M, Yoshimatsu K, Amagase N, Ooshima T, Kubo N. Studies on diagnostic criteria for gestational diabetes mellitus by 75 g glucose tolerance test.  Asia-Oseania J Obstet Gynaecol. 1987;  13 187-193
    PubMedGoogle Scholar
  • 2 Spellacy W N, Buhi W C, Birk S A. Carbohydrate metabolism in women with a twin pregnancy.  Obstetrics and Gynecology. 1980;  55 688-691
    PubMedGoogle Scholar
  • 3 Dwayer P L, Oats J N, Walstab J E, Beischer N A. Glucose tolerance in pregnancy.  Aust NZ J Obstet Gynaec. 1982;  22 131-134
    PubMedGoogle Scholar
  • 4 Moodley S P, Jialal I, Moodley J, Naicker R S, Marivate M. Carbohydrate metabolism in African women with twin.  Diabetes Care. 1984;  7 72-74
    PubMedGoogle Scholar
  • 5 Henderson C E, Scarpelli S, LaRosa D, Divon M Y. Assessing the risk of gestational diabetes in twin gestation.  J Natl Med Assoc. 1995;  87 757-758
    PubMedGoogle Scholar

M. Mitao

Hiroshima City Asa Hospital

2-1-1 Kabeminami Asakita · Hiroshima · Japan ·

Phone: + 81 (82) 815-5211

Fax: + 81 (82) 814-1791

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