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Horm Metab Res 2002; 34(7): 389-393
DOI: 10.1055/s-2002-33471
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Effects of the β3 Adrenergic Receptor Agonist on Developmental Obesity in Oophorectomized Rats

M.  Tomita1 , T.  Kurabayashi1 , H.  Matsushita1 , A.  Honda1 , K.  Tanaka1
  • 1Department of Obstetrics and Gynecology, Niigata University, Faculty of Medicine, Niigata, Japan
Further Information

Publication History

Received: 9 October 2001

Accepted after revision: 12 March 2002

Publication Date:
21 August 2002 (online)

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Abstract

In this study, we evaluated the anti-obesity effects of selective β3 adrenergic receptor agonist (ARa) and/or a diet in oophorectomized (OVX) treatment in obese rats. Ten-week-old female Sprague-Dawley rats were divided into 4 groups: (1) OVX; (2) OVX treated with β3 ARa, BRL 35 135; (3) sham-operated controls (sham group); (4) sham-treated with β3 ARa (sham+ARa group). These four groups were divided into two groups, one on ad libitum diet, and the other on a diet of limited chow. The effects of β3 ARa on body weight, intraabdominal fat weight, adipocyte volume, serum lipid content, and serum leptin were measured after 4 weeks had been completed. On both the ad libitum and the limited diet, ARa significantly reduced the ratio of intraabdominal fat and body weight (IAF ratio) regardless whether in the OVX or sham group, although ARa had no influence on weight gain. On the ad libitum diet, the serum leptin was significantly increased after OVX, and significantly reduced after ARa administration. ARa significantly reduced the volume of intraabdominal adipocytes. We conclude that ARa reduces intraabdominal fat without reducing body weight in oophorectomized rats. The serum parameter affected differently to rats on the ad libitum diet and on the limited diet.

Key words

Estrogen - Diet - Lipolysis - Leptin - Adipocyte

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M. Tomita, M.D.

Department of Obstetrics and Gynecology, Niigata University, Faculty of Medicine ·

1-757 Asahimachi-dori Niigata · Niigata, 951-8510 · Japan ·

Phone: + 81 (25) 227-2320 ·

Fax: + 81 (25) 227-0789

Email: m-tomita@med.niigata-u.ac.jp

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