Adenoviral Insulin Gene Therapy Prolongs Survival of IDDM Model BB Rats by Improving Hyperlipidemia

Abstract

Diabetes is frequently associated with hyperlipidemia, which results in atherogenic complications. Insulin-dependent diabetes mellitus (IDDM) model BB/Wor//Tky (BB) rats exhibit both hyperglycemia and hyperlipidemia and die within 3 weeks after the onset of diabetes unless insulin therapy is given. We performed insulin gene therapy in BB rats with adenovirus vectors through the tail vein. After infusion, plasma triglyceride levels dropped quickly and maintained low levels for 1 week, whereas blood glucose levels showed a slight decrease. The survival period of diabetic BB rats was prolonged to up to 75 days by infusing insulin gene-expressing adenoviral vectors. We suggest that the control of hyperlipidemia can be a life-saving measure when combined with hyperglycemia control in the treatment of diabetes.

Key words

Insulin Gene Therapy - IDDM Model BB Rats - Hyperlipidemia - Hypertriglyceridemia - Hyperglycemia - Adenoviral Gene Delivery

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