Download PDF
Semin Neurol 2002; 22(2): 149-156
DOI: 10.1055/s-2002-36538
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Percutaneous Vertebroplasty: An Emerging Therapy for Vertebral Compression Fractures

Perry P. Ng, Louis P. Caragine, Jr., Christopher F. Dowd
  • Interventional Neuroradiology Section, University of Southern California San Francisco, San Francisco, California
Further Information

Publication History

Publication Date:
13 January 2003 (online)

    Permissions and Reprints

ABSTRACT

Osteoporosis is a debilitating disease that occurs in epidemic proportions in Western societies and has a large economic impact. Percutaneous vertebroplasty is successful in alleviating subacute and chronic pain caused by osteoporotic compression fractures and pathological vertebral fractures from tumor infiltration. The technique is safe and can be performed on an outpatient basis utilizing high-resolution fluoroscopy.

KEYWORDS

Vertebral - osteoporosis - spine - vertebroplasty - percutaneous - technique - compression - fracture

REFERENCES

  • 1 Garfin S R, Yuan H A, Reiley M A. New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures.  Spine . 2001;  26 1511-1515
    Google Scholar
  • 2 Riggs B L, Melton III J L. The worldwide problem of osteoporosis: insights afforded by epidemiology.  Bone . 1995;  17 505S-511S
    CrossrefPubMedGoogle Scholar
  • 3 Cooper C, Atkinson E J, O'Fallon W M, Melton III J L. Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989.  J Bone Miner Res . 1992;  7 221-227
    CrossrefPubMedGoogle Scholar
  • 4 Melton III J L. Epidemiology of spinal osteoporosis.  Spine . 1997;  22 2S-11S
    CrossrefPubMedGoogle Scholar
  • 5 Kado D M, Browner W S, Palermo L. Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group.  Arch Intern Med . 1999;  159 1215-1220
    Google Scholar
  • 6 Leech J A, Dulberg C, Kellie S. Relationship of lung function to severity of osteoporosis in women.  Am Rev Respir Dis . 1990;  141 68-71
    CrossrefPubMedGoogle Scholar
  • 7 Silverman S L. The clinical consequences of vertebral compression fracture.  Bone . 1992;  13(suppl 2) S27-S31<
    CrossrefPubMedGoogle Scholar
  • 8 Nelson D A, Kleerekoper M, Peterson E L. Reversal of vertebral deformities in osteoporosis: measurement error or ``rebound''?.  J Bone Miner Res . 1994;  9 977-982
    PubMedGoogle Scholar
  • 9 Mathis J M, Barr J D, Belkoff S M. Percutaneous vertebroplasty: a developing standard of care for vertebral compression fractures.  AJNR Am J Neuroradiol . 2001;  22 373-381
    PubMedGoogle Scholar
  • 10 Harrington K D, Sim F H, Enis J E. Methylmethacrylate as an adjunct in internal fixation of pathological fractures: experience with three hundred and seventy-five cases.  J Bone Joint Surg Am . 1976;  58 1047-1055
    PubMedGoogle Scholar
  • 11 Persson B M, Ekelund L, Lovdahl R, Gunterberg B. Favourable results of acrylic cementation for giant cell tumors.  Acta Orthop Scand . 1984;  55 209-214
    CrossrefPubMedGoogle Scholar
  • 12 Mavian G Z, Okulski C J. Double fixation of metastatic lesions of the lumbar and cervical vertebral bodies utilizing methylmethacrylate compound: report of a case and review of a series of cases.  J Am Osteopath Assoc . 1986;  86 153-157
    PubMedGoogle Scholar
  • 13 Galibert P, Deramond H, Rosat P, Le Gars D. [Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty].  Neurochirurgie . 1987;  33 166-168
    PubMedGoogle Scholar
  • 14 Cardon T, Hachulla E, Flipo R M. Percutaneous vertebroplasty with acrylic cement in the treatment of a Langerhans cell vertebral histiocytosis.  Clin Rheumatol . 1994;  13 518-521
    CrossrefPubMedGoogle Scholar
  • 15 Cotten A, Boutry N, Cortet B. Percutaneous vertebroplasty: state of the art.  Radiographics . 1998;  18 311-323
    PubMedGoogle Scholar
  • 16 Kaufmann T J, Jensen M E, Schweickert P A. Age of fracture and clinical outcomes of percutaneous vertebroplasty.  AJNR Am J Neuroradiol . 2001;  22 1860-1863
    PubMedGoogle Scholar
  • 17 Amar A, Larsen D, Esnaashari N. Percutaneous transpedicular polymethylmethacrylate vertebroplasty for treatment of spinal compression fractures.  Neurosurgery . 2001;  49 1105-1115
    PubMedGoogle Scholar
  • 18 O'Brien J P, Sims J T, Evans A J. Vertebroplasty in patients with severe vertebral compression fractures: a technical report.  AJNR Am J Neuroradiol . 2000;  21 1555-1558
    PubMedGoogle Scholar
  • 19 Jensen M E, Evans A J, Mathis J M. Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects.  AJNR Am J Neuroradiol . 1997;  18 1897-1904
    PubMedGoogle Scholar
  • 20 Padovani B, Kasriel O, Brunner P, Peretti-Viton P. Pulmonary embolism caused by acrylic cement: a rare complication of percutaneous vertebroplasty.  AJNR Am J Neuroradiol . 1999;  20 375-377
    PubMedGoogle Scholar
  • 21 Maynard A S, Jensen M E, Schweickert P A. Value of bone scan imaging in predicting pain relief from percutaneous vertebroplasty in osteoporotic vertebral fractures.  AJNR Am J Neuroradiol . 2000;  21 1807-1812
    PubMedGoogle Scholar
  • 22 Dean J R, Ison K T, Gishen P. The strengthening effect of percutaneous vertebroplasty.  Clin Radiol . 2000;  55 471-476
    CrossrefPubMedGoogle Scholar
  • 23 Levine S A, Perin L A, Hayes D, Hayes W S. An evidence-based evaluation of percutaneous vertebroplasty.  Manag Care . 2000;  9 56-63
    PubMedGoogle Scholar
  • 24 San Millan Ruiz D, Burkhardt K, Jean B. Pathology findings with acrylic implants.  Bone . 1999;  25 85S-90S
    CrossrefPubMedGoogle Scholar
  • 25 Deramond H, Wright N T, Belkoff S M. Temperature elevation caused by bone cement polymerization during vertebroplasty.  Bone . 1999;  25 17S-21S
    CrossrefPubMedGoogle Scholar
  • 26 Ray Jr E C. Interventional radiology in cancer patients.  Am Fam Physician . 2000;  62 95-102
    PubMedGoogle Scholar
  • 27 Barr J D, Barr M S, Lemley T J, McCann R M. Percutaneous vertebroplasty for pain relief and spinal stabilization Spine .  2000;  25 923-928
    CrossrefPubMedGoogle Scholar
  • 28 Tohmeh A G, Mathis J M, Fenton D C. Biomechanical efficacy of unipedicular versus bipedicular vertebroplasty for the management of osteoporotic compression fractures.  Spine . 1999;  24 1772-1776
    CrossrefPubMedGoogle Scholar
  • 29 Liebschner M A, Rosenberg W S, Keaveny T M. Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty.  Spine . 2001;  26 1547-1554
    CrossrefPubMedGoogle Scholar
  • 30 Belkoff S M, Mathis J M, Jasper L E, Deramond H. The biomechanics of vertebroplasty: the effect of cement volume on mechanical behavior.  Spine . 2001;  26 1537-1541
    CrossrefPubMedGoogle Scholar
  • 31 Cotten A, Dewatre F, Cortet B. Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up.  Radiology . 1996;  200 525-530
    CrossrefPubMedGoogle Scholar
  • 32 Weill A, Chiras J, Simon J M. Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement.  Radiology . 1996;  199 241-247
    PubMedGoogle Scholar
  • 33 Cotten A, Deramond H, Cortet B. Preoperative percutaneous injection of methyl methacrylate and N-butyl cyanoacrylate in vertebral hemangiomas.  AJNR Am J Neuroradiol . 1996;  17 137-142
    PubMedGoogle Scholar
  • 34 Deramond H, Darrasson R, Galibert P. Percutaneous vertebroplasty with acrylic cement in the treatment of aggressive spinal angiomas.  Rachis . 1989;  1 143-153
    PubMedGoogle Scholar
  • 35 Melton III J L. Excess mortality following vertebral fracture.  J Am Geriatr Soc . 2000;  48 338-339
    PubMedGoogle Scholar
  • 36 Hitchon P W, Goel V, Drake J. Comparison of the biomechanics of hydroxyapatite and polymethylmethacrylate vertebroplasty in a cadaveric spinal compression fracture model.  J Neurosurg . 2001;  95 215-220
    PubMedGoogle Scholar
      >