Semin Neurol 2002; 22(3): 321-328
DOI: 10.1055/s-2002-36651
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Sleep and Epilepsy

Carl W. Bazil
  • The Neurological Institute, New York, New York
Further Information

Publication History

Publication Date:
15 January 2003 (online)

ABSTRACT

Quality sleep is essential for patients with epilepsy, but this aspect of their treatment is frequently overlooked. Sleep disturbance can result in daytime drowsiness, worsening memory, and deteriorating seizure control. In a few patients, recognition and treatment of a coexisting sleep disorder can make the difference between complete seizure control and refractory epilepsy. Sleep has effects on interictal epileptiform discharges, with particular implications for diagnostic studies. Sleep disorders can coexist with epilepsy, leading to errors in diagnosis and worsening of seizures. Some specific syndromes demonstrate unique properties related to sleep. Seizures themselves disrupt sleep, even when occurring during the day, with the potential for persistent drowsiness and, perhaps, further memory dysfunction. Finally, most patients with epilepsy are treated with anticonvulsant drugs, some of which can have adverse (or beneficial) effects on sleep.

REFERENCES

  • 1 Gibbs E, Gibbs F. Diagnostic and localizing value of electroencephalographic studies in sleep.  Assoc Res Nerv Ment Dis . 1947;  26 366-377
  • 2 Malow B A, Selwa L M, Ross D, Aldrich M S. Lateralizing value of interictal spikes on overnight sleep-EEG studies in temporal lobe epilepsy.  Epilepsia . 1999;  40 1587-1592
  • 3 Fountain N B, Kim J S, Lee S I. Sleep deprivation activates epileptiform discharges independent of the activating effects of sleep.  J Clin Neurophysiol . 1998;  15 69-75
  • 4 Sammaritano M, Gigli G L, Gotman J. Interictal spiking during wakefulness and sleep and localization of foci in temporal lobe epilepsy.  Neurology . 1991;  41 290-297
  • 5 Malow B A, Lin X, Kushwaha R, Aldrich M S. Interictal spiking increases with sleep depth in temporal lobe epilepsy.  Epilepsia . 1998;  39 1309-1316
  • 6 Malow B A, Aldrich M S. Localizing value of rapid eye movement sleep in temporal lobe epilepsy.  Sleep Med . 2000;  1 57-60
  • 7 Sammaritano M R, Saint-Hilaire J-M. Contribution of interictal spiking during sleep to localization of extratemporal epileptic foci [abstract].  Epilepsia . 1998;  39 (suppl 6) 75
  • 8 Sammaritano M R, Letova V B, Saint-Hilaire J M. Nocturnal seizures in temporal lobe epilepsy patients: ultradian rhythmicity and alterations in sleep microstructure [abstract].  Epilepsia . 1995;  36 (suppl 4) 152
  • 9 Malow B A, Bowes R J, Lin X. Predictors of sleepiness in epilepsy patients.  Sleep . 1997;  20 1105-1110
  • 10 Stores G, Wiggs L, Campling G. Sleep disorders and their relationship to psychological disturbances in children with epilepsy.  Child Care Health Dev . 1998;  24 5-19
  • 11 Cortesi F, Giannotti F, Ottaviano S. Sleep problems and daytime behavior in childhood idiopathic epilepsy.  Epilepsia . 1999;  40 1557-1565
  • 12 Malow B A, Fromes G, Aldrich M S. Usefulness of polysomnography in epilepsy patients.  Neurology . 1997;  48 1389-1394
  • 13 Beran R G, Plunkett M J, Holland G J. Interface of epilepsy and sleep disorders.  Seizure . 1999;  8 97-102
  • 14 Provini F, Plazzi G, Tinuper P, Vandi S, Lugaresi E, Montagna P. Nocturnal frontal lobe epilepsy. A clinical and polygraphic overview of 100 consecutive cases.  Brain . 1999;  122 1017-1031
  • 15 Oldani A, Zucconi M, Asselta R. Autosomal dominant nocturnal frontal lobe epilepsy. A video-polysomnographic and genetic appraisal of 40 patients and delineation of the epileptic syndrome.  Brain . 1998;  121 205-223
  • 16 Tachibana N, Shinde A, Ikeda A, Akiguchi I, Kimura J, Shibasaki H. Supplementary motor area seizure resembling sleep disorder.  Sleep . 1996;  19 811-816
  • 17 Nakken K O, Magnusson A, Steinlein O K. Autosomal dominant nocturnal frontal lobe epilepsy: an electroclinical study of a Norwegian family with ten affected members.  Epilepsia . 1999;  40 88-92
  • 18 Wolf P, Schmitt J J. Awakening epilepsies and juvenile myoclonic epilepsy. In: Bazil CW, Malow BA, Sammaritano MR, eds. Sleep and Epilepsy: The Clinical Spectrum Amsterdam: Elsevier 2002: 237-243
  • 19 Wolf P, Okujava N. Possibilities of non-pharmacological conservative treatment of epilepsy.  Seizure . 1999;  8 45-52
  • 20 Dalla Bernardina B, Beghini G. Rolandic spikes in children with and without epilepsy.  Epilepsia . 1976;  17 161-167
  • 21 Lerman P, Kivity S. Benign focal epilepsy of childhood. A follow up of 100 recovered patients.  Arch Neurol . 1975;  32 261-264
  • 22 Panayiatopoulos C P. Early onset benign childhood occipital seizure susceptibility syndrome: a syndrome to recognize.  Epilepsia . 1999;  40 621-630
  • 23 O'Regan M E, Brown J K, Goodwin G M, Clarke M. Epileptic aphasia: a consequence of regional hypometabolic encephalopathy?.  Dev Med Child Neurol . 1998;  40 508-516
  • 24 Veggiotti P, Beccaria F, Guerrini R, Capvilla G, Lanzi G. Continuous spike-and-wave activity during slow-wave sleep: syndrome or EEG pattern?.  Epilepsia . 1999;  40 1593-1601
  • 25 Crespel A, Baldy-Moulinier M, Coubes P. The relationship between sleep and epilepsy in frontal and temporal lobe epilepsies: practical and physiopathologic considerations.  Epilepsia . 1998;  39 150-157
  • 26 Bazil C W, Walczak T S. Effects of sleep and sleep stage on epileptic and nonepileptic seizures.  Epilepsia . 1997;  38 56-62
  • 27 Herman S T, Walczak T S, Bazil C W. Distribution of partial seizures during the sleep-wake cycle: differences by seizure onset site.  Neurology . 2001;  56 1453-1458
  • 28 Park S A, Lee B I, Lee S J, Kim W J, Lee J H, Kim J Y. Clinical courses of pure sleep epilepsies.  Seizure . 1998;  7 369-377
  • 29 Yaqub B A, Waheed G, Kabiraj M M. Nocturnal epilepsies in adults.  Seizure . 1997;  6 145-149
  • 30 Malow B A, Passaro E A, Milling C. Sleep deprivation does not affect seizure frequency during inpatient video-EEG monitoring.  Neurology . 2002;  59 1371-1374
  • 31 Quigg M, Straume M, Menaker M, Bertram E H. Temporal distribution of partial seizures: comparison of an animal model with human partial epilepsy.  Ann Neurol . 1998;  43 748-755
  • 32 Bazil C W, Short D W, Crispin D, Zheng W. Patients with intractable epilepsy have low melatonin, which increases following seizures.  Neurology . 2000;  55 1746-1748
  • 33 Fauteck J-D, Schmidt H, Lerchl A, Kurlemann G, Wittkowski W. Melatonin in epilepsy: first results of replacement therapy and first clinical results.  Biol Signals Recept . 1999;  8 105-110
  • 34 Peled N, Shorer Z, Peled E, Pillar G. Melatonin effect on seizures in children with severe neurologic deficit disorders.  Epilepsia. 2001;  42 1208-1210
  • 35 Besset A. Influence of generalized seizures on sleep organization. In: Sterman MB, Shouse MN, Passouant P, eds. Sleep and Epilepsy New York: Academic Press 1982: 339-346
  • 36 Touchon J, Baldy-Moulinier M, Billiard M, Besset A, Valmier J, Cadilhac J. Organisation du sommeil dans l'épilepsie récente du lobe temporal avant et après traitment par carbamazepine.  Rev Neurol . 1987;  143 462-467
  • 37 Bazil C W, Castro L HM, Walczak T S. Reduction of rapid eye movement sleep by diurnal and nocturnal seizures in temporal lobe epilepsy.  Arch Neurol . 2000;  57 363-368
  • 38 Wolf O, Roder-Wanner U U, Brede M. Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy.  Epilepsia . 1984;  25 467-475
  • 39 Wooten V D, Buysse D J. Sleep in psychiatric disorders. In: Chokroverty S, ed. Sleep Disorders Medicine Boston: Butterworth Heinemann 1999: 573-586
  • 40 Sammaritano M R, Sherwin A. Effects of anticonvulsants on sleep. In: Bazil CW, Malow BA, Sammaritano MR, eds. Sleep and Epilepsy: The Clinical Spectrum Amsterdam: Elsevier 2002: 187-194
  • 41 Chokroverty S, Quinto C. Sleep and epilepsy. In: Chokroverty S, ed. Sleep Disorders Medicine Boston: Butterworth Heinemann 1999: 697-727
  • 42 Drake M E, Pakalnis A, Bogner J E, Andrews J M. Outpatient sleep recording during antiepileptic drug monotherapy.  Clin Electroencephalogr . 1990;  21 170-173
  • 43 Placidi F, Diomedi M, Scalise A, Marciani M G, Romigi A, Gigli G L. Effect of anticonvulsants on nocturnal sleep in epilepsy.  Neurology . 2000;  54 (suppl 1) S25-S32
  • 44 Rao M L, Clarenbach P, Vahlensieck M., Kratzschmar S. Gabapentin augments whole blood serotonin in healthy young men.  J Neural Transm . 1988;  73 129-134
  • 45 Hening W A, Allen R, Walters A S, Chokroverty S. Motor functions and dysfunctions of sleep. In: Chokroverty S, ed. Sleep Disorders Medicine Boston: Butterworth Heinemann 1999: 441-507
  • 46 Salinsky M C, Oken B S, Binder L M. Assessment of drowsiness in epilepsy patients receiving chronic antiepileptic drug therapy.  Epilepsia . 1996;  37 181-187
  • 47 Stickgold R, Whidbee D, Schirmer B, Patel V, Hobson J A. Visual discrimination task improvement: a multi-step process occurring during sleep.  J Cogn Neurosci . 2000;  12 246-254
  • 48 Louie K, Wilson M A. Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep.  Neuron . 2001;  29 145-156
  • 49 Stickgold R, Hobson J A, Fosse R, Fosse M. Sleep, learning, and dreams: off-line memory reprocessing.  Science . 2001;  294 1052-1057
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