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Int J Sports Med 2005; 26(1/02): 9-15
DOI: 10.1055/s-2004-815817
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Blood Rheological Responses to Running and Cycling: A Potential Effect on the Arterial Hypoxemia of Highly Trained Athletes?

O. Galy1 , O. Hue1 , A. Boussana2 , C. Peyreigne3 , J. Mercier3 , C. Préfaut3
  • 1UPRES EA 3596, Laboratoire ACTES, UFR-STAPS Antilles-Guyane, Pointe à Pitre, France
  • 2UPRES EA 2991, Laboratoire Sport, Performance, Santé, UFR-STAPS, Montpellier, France
  • 3UPRES EA 701 “Laboratoire de Physiologie des Interactions”, Service Central de Physiologie Clinique, Centre Hospitalier Universitaire Arnaud de Villeneuve, Montpellier, France
Further Information

Publication History

Accepted after revision: November 20, 2003

Publication Date:
26 July 2004 (online)

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Abstract

To investigate 1) the blood rheological responses to high training volume and 2) the potential effect of these responses on arterial hypoxemia induced during submaximal running and cycling, 10 triathletes performed an incremental cycle test, 20 minutes of running (R), and 20 minutes of cycling (C). All trials were performed at nearly 75 % of V·O2max. Hematocrit (H), blood viscosity (ηb), plasma viscosity (ηpl), index of erythrocyte rigidity (Tk), changes in plasma volume (ΔPV), pulmonary diffusing capacity (DLco), and arteriolized blood gas (PaO2) were measured before and after each trial. Pulse oxymetry (SpO2) and cardioventilatory data were collected continuously. A significant increase in ηb, ηpl, and H was noted after R and C with respect to pre-exercise, whereas ΔPV decreased, with a greater decrease after C. Tk was significantly higher after R than after C. A significantly greater drop in DLco was noted after C compared with R. SpO2 decreased significantly more during R, as did PaO2. We conclude that blood rheological responses are specific to running and cycling. Cycling induced a sharp decrease in plasma volume, which could partially explain the greater DLco alteration. Running was characterized by an increase in Tk, which could be implicated in the severity of the drop in arterial oxygenation observed.

Key words

DLco - EIAH - hemorrheology - endurance athletes - triathlon

References

  • 1 Aillaud M F, Poisson C, Buonocore M, Billerey M, Lefevre P, Juhan-Vague I. Etude du viscosimètre médical à chute de bille.  Le Pharmacien Biologiste. 1985;  159 291-294
    PubMedGoogle Scholar
  • 2 Beaver W L, Wasserman K, Whipp B J. A new method for detecting anaerobic threshold by gas exchange.  J Appl Physiol. 1986;  60 2020-2027
    CrossrefPubMedGoogle Scholar
  • 3 Betticher D, Reinhart W, Geiser J. Effect of RBC shape and deformability on pulmonary O2 diffusing capacity and resistance to flow in rabbit lungs.  J Appl Physiol. 1995;  78 778-783
    PubMedGoogle Scholar
  • 4 Bonnen G E, Baker S K, Hatta H. Lactate transport and lactate transporters in skeletal muscle.  Can J Appl Physiol. 1997;  22 531-552
    PubMedGoogle Scholar
  • 5 Brun J F, Micallef J F, Orsetti A. Hemorheologic effects of light prolonged exercise.  Clin Hemorheol Microcirc. 1994;  14 807-818
    PubMedGoogle Scholar
  • 6 Brun J F, Khaled S, Raynaud E, Bouix D, Micallef J F, Orsetti A. Triphasic effects of exercise on blood rheology which relevance to physiology and pathophysiology?.  Clin Hemorheol Microcirc. 1998;  19 89-104
    PubMedGoogle Scholar
  • 7 Bshouty Z, Younes M. Effect of breathing pattern and level of ventilation on pulmonary fluid filtration in dog lung.  Am J Respir Physiol. 1992;  145 372-376
    PubMedGoogle Scholar
  • 8 Caillaud C, Connes P, Bouix D, Mercier J. Does haemorrheology explain the paradox of hypoxemia during exercise in elite athletes or thoroughbred horses?.  Clin Hemorheol Microcirc. 2002;  26 175-181
    PubMedGoogle Scholar
  • 9 Carre F, Durand F, Beillot J, Le Goff M C, Genetet B, Rochcongar P, Delamaire M. Altérations hémathologiques et hémorhéologiques secondaires à la pratique d'un exercice d'intensité maximale et spécifique de la spécialité sportive. Etude chez des sportifs de haut-niveau d'entraînement. Bidet JM, Boudart D, Delamaire M, Durand F Hémorhéologie et Facteurs de Risque. Proceeding of a Symposium Held in Rennes. 1990: 78-79
    Google Scholar
  • 10 Connes P, Bouix D, Kippelen P, Préfaut C, Caillaud C. Blood viscosity in athletes with exercise-induced hypoxemia.  Pflüg Arch. 2001;  442 86
    PubMedGoogle Scholar
  • 11 Convertino V, Keil L, Bernauer E, Greenleaf J. Plasma volume, osmolality, vasopressin and renin activity during graded exercise in man.  J Appl Physiol. 1981;  50 123-128
    PubMedGoogle Scholar
  • 12 Cotes J E. Lung Function: Assessment and Application in Medicine. 4th ed. Oxford; Blackwell Scientific Publications 1979: 203-329
    Google Scholar
  • 13 Davidson R J, Robertson J D, Maughan R J. Haematological changes due to triathlon competition.  Br J Sports Med. 1986;  20 159-161
    PubMedGoogle Scholar
  • 14 Dempsey J A, Hanson P, Hendersen K. Exercise-induced arterial hypoxemia in healthy human subjects at sea level.  J Appl Physiol. 1984;  355 161-175
    CrossrefPubMedGoogle Scholar
  • 15 Dintenfass L. Red cell rigidity, “TK”, and filtration.  Clin Hemorheol. 1985;  5 241-244
    PubMedGoogle Scholar
  • 16 Doyle M P, Galey W R, Walker B R. Reduced erythrocyte deformability alters pulmonary hemodynamics.  J Appl Physiol. 1989;  67 2593-2599
    PubMedGoogle Scholar
  • 17 Durand F, Mucci P, Préfaut C. Evidence for an inadequate hyperventilation inducing arterial hypoxemia at submaximal exercise in all highly trained endurance athletes.  Med Sci Sports Exerc. 2000;  32 926-932
    PubMedGoogle Scholar
  • 18 Fons C, Brun J F, Supparo I, Mallard C, Bardet C, Orsetti A. Evaluation of blood viscosity at high shear rate with a falling ball viscometer.  Clin Hemorheol. 1993;  13 651-659
    PubMedGoogle Scholar
  • 19 Galy O, Hue O, Le Gallais D, Peyreigne C, Boussana A, Libicz S, Préfaut C. Is exercise-induced desaturation activity-dependent?.  Pflügers Arch. 2001;  442 93
    PubMedGoogle Scholar
  • 20 Galy O, Hue O, Boussana A, Le Gallais D, Préfaut C. Cardiorespiratory responses and blood lactate during an experimental run-cycle transition in duathletes.  Int J Sports Med. 2002;  23 162-167
    Article in Thieme ConnectPubMedGoogle Scholar
  • 21 Gueguen-Duchesne M, Durand F, Beillot J, Dezier J F, Rochcongar P, Le Goff M C, Pommereuil M, Genetet B. Could maximal exercise be a hemorheological risk factor?.  Clin Hemorheol. 1987;  7 418
    PubMedGoogle Scholar
  • 22 Guezennec C Y, Nadaud J F, Satabin P, Léger C, Laffargue P. Influence of poly-insatured fatty acid diet on the hemorheological response to physical exercise in hypoxia.  Int J Sports Med. 1989;  10 286-291
    PubMedGoogle Scholar
  • 23 Hue O, Le Gallais D, Chollet D, Boussana A, Préfaut C. Ventilatory responses during experimental cycle-run transition in triathletes.  Med Sci Sports Exerc. 1999;  10 1422-1428
    PubMedGoogle Scholar
  • 24 Hue O, Le Gallais D, Chollet D, Préfaut C. Ventilatory threshold and maximal oxygen uptake in present triathletes.  Can J Appl Physiol. 2000;  25 102-113
    PubMedGoogle Scholar
  • 25 Hue O, Le Gallais D, Boussana A, Chollet D, Préfaut C. Performance level and cardiopulmonary responses during a cycle-run trial.  Int J Sports Med. 2000;  21 250-255
    Article in Thieme ConnectPubMedGoogle Scholar
  • 26 Hue O, Le Gallais D, Préfaut C. Specific pulmonary responses during the cycle-run succession in triathletes.  Scan J Med Sports Med. 2001;  11 355-361
    PubMedGoogle Scholar
  • 27 Kinderman W, Simon M, Keul J. The significance of the aerobic-anaerobic transition for the determination of work load intensities during endurance training.  Eur J Appl Physiol. 1979;  42 25-34
    CrossrefPubMedGoogle Scholar
  • 28 Martin B, Powers S, Cicale M, Collop N, Huang D, Criswell D. Validity of pulse oxymetry during exercise in elite endurance athletes.  J Appl Physiol. 1992;  72 455-458
    PubMedGoogle Scholar
  • 29 Martins J, e Silva D. Blood rheological adaptation to physical exercise.  Rev Port Hemorreol. 1988;  2 63-67
    PubMedGoogle Scholar
  • 30 McNaughon L M. Plasma volume responses associated with a sprint triathlon in novice triathletes.  Int J Sports Med. 1989;  3 161-164
    PubMedGoogle Scholar
  • 31 Miles D, Doerr E C, Schonfeld A S, Sinks E D, Gotshall W. Changes in pulmonary diffusing capacity and closing volume after running a marathon.  Respir Physiol. 1983;  52 349-359
    CrossrefPubMedGoogle Scholar
  • 32 Nihill M R, McNamara D G, Vick R L. The effects of increased blood viscosity on pulmonary vascular resistance.  Am Heart J. 1976;  92 65-72
    CrossrefPubMedGoogle Scholar
  • 33 Préfaut C, Durand F, Mucci P, Caillaud C. Exercise-induced hypoxemia in athletes: a review.  Sport Med. 2000;  30 47-61
    PubMedGoogle Scholar
  • 34 Senay L CJR, Rogers G, Jooste P. Changes in blood plasma during progressive treadmill and cycle exercise.  J Appl Physiol: Respirat Environ Exerc Physiol. 1987;  49 59-65
    PubMedGoogle Scholar
  • 35 Teillet T, Pilardeau P, Libercier P, Vaysse J, Hermant J L. Variation des protéines plasmatiques pendant un exercice de courte durée.  Sci Sports. 1991;  6 173-178
    PubMedGoogle Scholar
  • 36 Tong S, Nasrawi F, Marletta F, Fanari P, Agosti R, Longhini R. Hemorheology during exercise: is there a microcirculatory relationship?.  Biorheology. 1995;  32 400
    PubMedGoogle Scholar
  • 37 Wells L C, Stern J R, Kohrt W M, Campbell K D. Fluid shifts with successive running and bicycling performance.  Med Sci Sports Exerc. 1987;  19 137-142
    PubMedGoogle Scholar
  • 38 Wood S C, Doyle M P, Appenzeller O. Effects of endurance training and long distance running on blood viscosity.  Med Sci Sports Exerc. 1991;  23 1265-1269
    PubMedGoogle Scholar
  • 39 Yang R F, Zhao C J, Wu Y P, Wu X. Deformability of erythrocytes after exercises.  Biorheology. 1995;  32 250
    PubMedGoogle Scholar

O. Galy

BP 1287 Noumea

98845 Nouvelle-Calédonie

France

Phone: + 330468439401

Fax: + 33 04 68 43 94 01

Email: galy.o@wanadoo.fr

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