Antifungal Properties of Surangin B, a Coumarin from Mammea longifolia

Abstract

The natural product electron transport inhibitor surangin B was examined for its ability to inhibit in vitro mycelial growth and spore germination in several species of fungi. As an inhibitor of mycelial growth, surangin B showed strongest activity against Rhizoctonia solani (IC₅₀ = 3.8 μM) and Botrytis cinerea (IC₅₀ = 11.2 μM). Inhibitory effects were less pronounced in Alternaria dauci, Fusarium oxysporum and Penicillium sp. (IC₅₀ values > 30 μM) and absent in Trichoderma harzianum. Surangin B reduced the level of spore germination in Fusarium oxysporum (IC₅₀ = 2.3 μM) and Botrytis cinerea (IC₅₀ = 1.4 μM), although Alternaria dauci was considerably more tolerant of this coumarin (IC₅₀ = 500 μM). Our results indicate that surangin B may have potential as an antifungal agent.

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