Enantio- and Diastereoselective [3+2] Cycloadditions of Azomethine Ylides with Ag(I)-Phosphinooxazoline Catalysts

Abstract

Chiral Ag(I)-phosphinooxazoline (PHOX) complexes are efficient catalysts for [3+2] cycloadditions of azomethine ylides with α,β-unsaturated carboxylic esters. In intramolecular cycloadditions, virtually complete diastereocontrol and enantiomeric excesses of up to 99% have been observed.

Key words

asymmetric catalysis - Ag(I) complexes - [3+2] cyclo­addition - azomethine ylides - phosphinooxazolines

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