Anästhesiol Intensivmed Notfallmed Schmerzther 2005; 40(8): 453-458
DOI: 10.1055/s-2005-870100
Aktuelle Medizin und Forschung
© Georg Thieme Verlag KG Stuttgart · New York

Hygienemaßnahmen in der Anästhesie

Infection Control Measures in AnaesthesiaR.-P.  Vonberg1 , P.  Gastmeier1
  • 1Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover
Dieser Beitrag wird von einem Gasteditorial von K. E. Unertl und W. A. Krueger begleitet.
Further Information

Publication History

Publication Date:
03 April 2006 (online)

Zusammenfassung

Aus Unwissen, Unsicherheit, Bequemlichkeit oder vermeintlicher Sparsamkeit heraus werden Empfehlungen zur Infektionsprävention bei der Anästhesie nicht immer beachtet. Die wichtigsten sind: 1. für die Inhalationsnarkosen: Filter in Beatmungssystemen zum Rückhalt von Erregern können die Kontamination des Beatmungssystems verhindern, so dass dessen Aufbereitung nur einmal täglich oder bei Kontaminationen an der Außenseite notwendig ist; 2. für die Regionalanästhesie: Tragen von sterilen Handschuhen und Mund-Nasen-Schutz sowie eines sterilen Kittels; 3. für die intravenöse Anästhesie: Einmalmaterial zur intravenösen Applikation von Substanzen ist nach jedem Patienten vollständig zu verwerfen. Rückschlagventile in Infusionsleitungen bieten keinen verlässlichen Schutz vor Kontaminationen des Systems. Restmengen von Parenteralia, die vom Hersteller zur einmaligen Anwendung an einem Patienten deklariert sind, sollen verworfen werden.
Die alkoholische Händedesinfektion ist die wichtigste Maßnahme zur Vermeidung von Transmissionen und nosokomialen Infektionen.

Abstract

Several reasons such as ignorance, convenience, or economical considerations might lead to disobeying basic hygiene measures in anaesthesia. The most important recommendations are for: 1. General anaesthesia: bacterial filters prevent breathing circuit contamination from patient’s expiratory secretions. This way reprocessing of reusable components is required only once a day or in case an external contamination has occurred; 2. Neuraxial blockade: use of sterile gloves, a surgical face mask, and a sterile gown is recommended; 3. Intravenous anaesthesia: equipment not manufactured for re-use may not be used for more than one patient under any circumstances. One-way-valves do not securely prevent retrograde contamination of the infusion system. Do not use multi dose vials unless declared by manufacturer.

Alcoholic hand disinfection is the most important measure in order to avoid nosocomial pathogen transmission and infection.

Literatur

  • 1 Katz J D. Hand washing and hand disinfection: more than your mother taught you.  Anesthesiol Clin North America. 2004;  22 457-471
  • 2 Hajjar J, Girard R. Surveillance of nosocomial infections related to anesthesia. A multicenter study.  Ann Fr Anesth Reanim. 2000;  19 47-53
  • 3 Halkes M J, Snow D. Re-use of equipment between patients receiving total intravenous anaesthesia: a postal survey of current practice.  Anaesthesia. 2003;  58 582-587
  • 4 Panikkar K K, Yentis S M. Wearing of masks for obstetric regional anaesthesia. A postal survey.  Anaesthesia. 1996;  51 398-400
  • 5 Lacour M, Scherrer M, Dettenkofer M, Daschner F. Filter bei Beatmungstherapie.  Intensivmed. 1997;  34 153-158
  • 6 du Moulin G C, Saubermann A J. The anesthesia machine and circle system are not likely to be sources of bacterial contamination.  Anesthesiology. 1977;  47 353-358
  • 7 Adriani J, Rovenstine E A. Experimental studies on carbon dioxide absorbers for anesthesia.  Anesthesiology. 1941;  2 1-19
  • 8 Ziegler C, Jacoby J. Anesthetic equipment as a source of infection.  Curr Res Anesth Analg. 1956;  35 451-459
  • 9 Pandit S K, Mehta S, Agarwal S C. Risk of cross-infection from inhalation anaesthetic equipment.  Br J Anaesth. 1967;  39 838-844
  • 10 Dryden G E. Risk of contamination from the anesthesia circle absorber: an evaluation.  Anesth Analg. 1969;  48 939-943
  • 11 Stratford B C, Clark R R, Dixson S. The disinfection of anaesthetic apparatus.  Br J Anaesth. 1964;  36 471-476
  • 12 Beck A, Zadeh J A. Infection by anaesthetic apparatus.  Lancet. 1968;  1 533-534
  • 13 Meeks C H, Pembleton W E, Hench M E. Sterilization of anesthesia apparatus.  JAMA. 1967;  199 276-278
  • 14 Langevin P B, Rand K H, Layon A J. The potential for dissemination of Mycobacterium tuberculosis through the anesthesia breathing circuit.  Chest. 1999;  115 1107-1114
  • 15 Nielsen H, Vasegaard M, Stokke D B. Bacterial contamination of anaesthetic gases.  Br J Anaesth. 1978;  50 811-814
  • 16 Jenkins J RE, Edgar W M. Sterilisation of anaesthetic equipment.  Anaesthesia. 1964;  19 177-190
  • 17 Berry A J, Nolte F S. An alternative strategy for infection control of anesthesia breathing circuits: a laboratory assessment of the Pall HME Filter.  Anesth Analg. 1991;  72 651-655
  • 18 Daggan R, Zefeiridis A, Steinberg D, Larijani G, Gratz I, Goldberg M E. High-quality filtration allows reuse of anesthesia breathing circuits resulting in cost savings and reduced medical waste.  J Clin Anesth. 1999;  11 536-539
  • 19 Rathgeber J, Kietzmann D, Mergeryan H, Hub R, Zuchner K, Kettler D. Prevention of patient bacterial contamination of anaesthesia-circle-systems: a clinical study of the contamination risk and performance of different heat and moisture exchangers with electret filter (HMEF).  Eur J Anaesthesiol. 1997;  14 368-373
  • 20 Vezina D P, Trepanier C A, Lessard M R, Gourdeau M, Tremblay C. Anesthesia breathing circuits protected by the DAR Barrierbac S breathing filter have a low bacterial contamination rate. Can. J.  Anaesth.. 2001;  48 748-754
  • 21 Wilkes A R, Benbough J E, Speight S E, Harmer M. The bacterial and viral filtration performance of breathing system filters.  Anaesthesia. 2000;  55 458-465
  • 22 Vezina D P, Trepanier C A, Lessard M R, Gourdeau M, Tremblay C, Guidoin R. An in vivo evaluation of the mycobacterial filtration efficacy of three breathing filters used in anesthesia.  Anesthesiology. 2004;  101 104-109
  • 23 Bärwolff S, Geffers C, Rüden H. Beatmungsfilter - Einsatz im OP aus hygienischer Sicht. Der Hauptstadtkongress für Anästhesiologie und Intensivmedizin. 2003
  • 24 Morgan-Hughes N J, Turnbull D, Mills G H. Sudden upper airway obstruction due to invisible rain-out in the heat and moisture exchange filter (reply).  Br J Anaesth. 2002;  89 336
  • 25 Breathing System Filters. The Medicines and Healthcare Products Regulatory Agency (MHRA). MHRA Evaluation 04 005. 2004
  • 26 Garibaldi R A, Britt M R, Webster C, Pace N L. Failure of bacterial filters to reduce the incidence of pneumonia after inhalation anesthesia.  Anesthesiology. 1981;  54 364-368
  • 27 Garner J S, Jarvis W R, Emori T G, Horan T C, Hughes J M. CDC definitions for nosocomial infections, 1988.  Am J Infect Control. 1988;  16 128-140
  • 28 Feeley T W, Hamilton W K, Xavier B, Moyers J, Eger E I. Sterile anesthesia breathing circuits do not prevent postoperative pulmonary infection.  Anesthesiology. 1981;  54 369-372
  • 29 Tablan O C, Anderson L J, Besser R, Bridges C, Hajjeh R. Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee.  MMWR Recomm Rep. 2004;  53 1-36
  • 30 Murphy P M, Fitzgeorge R B, Barrett R F. Viability and distribution of bacteria after passage through a circle anaesthetic system.  Br J Anaesth. 1991;  66 300-304
  • 31 Clery G, Brimacombe J, Stone T, Keller C, Curtis S. Routine cleaning and autoclaving does not remove protein deposits from reusable laryngeal mask devices.  Anesth Analg. 2003;  97 1189-1191
  • 32 Coetzee G J. Eliminating protein from reusable laryngeal mask airways. A study comparing routinely cleaned masks with three alternative cleaning methods.  Anaesthesia. 2003;  58 346-353
  • 33 Brimacombe J, Stone T, Keller C. Supplementary cleaning does not remove protein deposits from re-usable laryngeal mask devices.  Can J Anaesth. 2004;  51 254-257
  • 34 Miller D M, Youkhana I, Karunaratne W U, Pearce A. Presence of protein deposits on “cleaned” re-usable anaesthetic equipment.  Anaesthesia. 2001;  56 1069-1072
  • 35 Task Force vCJK. Die Variante der Creutzfeldt-Jakob-Krankheit (vCJK). Bundesgesundheitsblatt. Gesundheitsforschung.  Gesundheitsschutz. 2002;  45 376-394
  • 36 Herwaldt L A, Pottinger J M, Coffin S A, Schulz-Stübner S. Nosocomial infections associated with anesthesia. In: Mayhall CG (ed) Hospital Epidemiology and Infection Control. Philadelphia; Lippincott Williams & Wilkins 2004: 1073-1115
  • 37 Holt H M, Andersen S S, Andersen O, Gahrn-Hansen B, Siboni K. Infections following epidural catheterization.  J Hosp Infect. 1995;  30 253-260
  • 38 Raad I I. The pathogenesis and prevention of central venous catheter-related infections.  Middle East J Anesthesiol. 1994;  12 381-403
  • 39 Schweizer R T. Mask wiggling as a potential cause of wound contamination.  Lancet. 1976;  2 1129-1130
  • 40 Philips B J, Fergusson S, Armstrong P, Anderson F M, Wildsmith J A. Surgical face masks are effective in reducing bacterial contamination caused by dispersal from the upper airway.  Br J Anaesth. 1992;  69 407-408
  • 41 McLure H A, Talboys C A, Yentis S M, Azadian B S. Surgical face masks and downward dispersal of bacteria.  Anaesthesia. 1998;  53 624-626
  • 42 Tunevall T G. Postoperative wound infections and surgical face masks: a controlled study.  World J Surg. 1991;  15 383-387
  • 43 Wildsmith J A. Regional anaesthesia requires attention to detail.  Br J Anaesth. 1991;  67 224-225
  • 44 Robert Koch-Institut. Richtlinie für Krankenhaushygiene und Infektionsprävention. München; Urban & Fischer Verlag Elsevier GmbH 2004
  • 45 O'Grady N P, Alexander M, Dellinger E P. et al . Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention.  MMWR Recomm Rep. 2002;  51 1-29
  • 46 American Society of Anesthesiologists. Recommendations for infection control for the practice of anesthesiology. 1999
  • 47 Sellors J E, Cyna A M, Simmons S W. Aseptic precautions for inserting an epidural catheter: a survey of obstetric anaesthetists.  Anaesthesia. 2002;  57 593-596
  • 48 O'Kelly S W, Marsh D. Face masks and spinal anaesthesia.  Br J Anaesth. 1993;  70 239
  • 49 Ritter M A, Eitzen H, French M L, Hart J B. The operating room environment as affected by people and the surgical face mask.  Clin Orthop. 1975;  111 147-150
  • 50 Kunkel S E, Warner M A. Human T-cell lymphotropic virus type III (HTLV-III) infection: how it can affect you, your patients, and your anesthesia practice.  Anesthesiology. 1987;  66 195-207
  • 51 Arbeitskreis Blut des Bundesministeriums für Gesundheit . Hepatitis-B-Virus (HBV). Bundesgesundheitsblatt. Gesundheitsforschung.  Gesundheitsschutz. 2000;  43 240-248
  • 52 Gerlich W H. Hepatitis B and C. Risk of transmission from infected health care workers to patients. Bundesgesundheitsblatt. Gesundheitsforschung.  Gesundheitsschutz. 2004;  47 369-378
  • 53 Trepanier C A. Transmission of hepatitis and AIDS: risks for the anaesthetist and the patient.  Can J Anaesth. 1991;  38 R98-R104
  • 54 Trepanier C A, Lessard M R, Brochu J G, Denault P H. Risk of cross-infection related to the multiple use of disposable syringes.  Can J Anaesth. 1990;  37 156-159
  • 55 Skubella U, Pfeiffer M. Indwelling catheters with injection ports: Is retrograde contamination of applied syringe possible?.  Anasthesiol Intensivmed Notfallmed Schmerzther. 1992;  27 359-360
  • 56 Crosby E. Intravenous infusions and one-way valves.  Can J Anaesth. 1991;  38 799-800
  • 57 CDC . Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease. Centers for Disease Control and Prevention.  MMWR Recomm Rep. 1998;  47 1-39
  • 58 Mattner F, Gastmeier P. Bacterial contamination of multiple-dose vials: a prevalence study.  Am J Infect Control. 2004;  32 12-16
  • 59 Kidd-Ljunggren K, Broman E, Ekvall H, Gustavsson O. Nosocomial transmission of hepatitis B virus infection through multiple-dose vials.  J Hosp Infect. 1999;  43 57-62
  • 60 Webster G J, Hallett R, Whalley S A. et al . Molecular epidemiology of a large outbreak of hepatitis B linked to autohaemotherapy.  Lancet. 2000;  356 379-384
  • 61 Alter M J, Ahtone J, Maynard J E. Hepatitis B virus transmission associated with a multiple-dose vial in a hemodialysis unit.  Ann Intern Med. 1983;  99 330-333
  • 62 Lagging L M, Aneman C, Nenonen N. et al . Nosocomial transmission of HCV in a cardiology ward during the window phase of infection: an epidemiological and molecular investigation.  Scand J Infect Dis. 2002;  34 580-582
  • 63 Bruguera M, Saiz J C, Franco S. et al . Outbreak of nosocomial hepatitis C virus infection resolved by genetic analysis of HCV RNA.  J Clin Microbiol. 2002;  40 4363-4366
  • 64 Kokubo S, Horii T, Yonekawa O, Ozawa N, Mukaide M. A phylogenetic-tree analysis elucidating nosocomial transmission of hepatitis C virus in a haemodialysis unit.  J Viral Hepat. 2002;  9 450-454
  • 65 Katzenstein T L, Jorgensen L B, Permin H. et al . Nosocomial HIV-transmission in an outpatient clinic detected by epidemiological and phylogenetic analyses.  AIDS. 1999;  13 1737-1744
  • 66 Michels H. Nosokomiale Staphylococcus-aureus-Infektionen: Infektionsserie ausgehend von kontaminierter Injektionsflüssigkeit.  Epidem Bull. 2000;  10 80
  • 67 Grohskopf L A, Roth V R, Feikin D R. et al . Serratia liquefaciens bloodstream infections from contamination of epoetin alfa at a hemodialysis center.  N Engl J Med. 2001;  344 1491-1497
  • 68 Simon P A, Chen R T, Elliott J A, Schwartz B. Outbreak of pyogenic abscesses after diphtheria and tetanus toxoids and pertussis vaccination.  Pediatr Infect Dis J. 1993;  12 368-371
  • 69 Pegues D A, Carson L A, Anderson R L. et al . Outbreak of Pseudomonas cepacia bacteremia in oncology patients.  Clin Infect Dis. 1993;  16 407-411
  • 70 Archibald L K, Ramos M, Arduino M J. et al . Enterobacter cloacae and Pseudomonas aeruginosa polymicrobial bloodstream infections traced to extrinsic contamination of a dextrose multidose vial.  J Pediatr. 1998;  133 640-644
  • 71 Tresoldi A T, Padoveze M C, Trabasso P. et al . Enterobacter cloacae sepsis outbreak in a newborn unit caused by contaminated total parenteral nutrition solution.  Am J Infect Control. 2000;  28 258-261
  • 72 Lacey S, Want S V. Pseudomonas pickettii infections in a paediatric oncology unit.  J Hosp Infect. 1991;  17 45-51
  • 73 Nakashima A K, McCarthy M A, Martone W J, Anderson R L. Epidemic septic arthritis caused by Serratia marcescens and associated with a benzalkonium chloride antiseptic.  J Clin Microbiol. 1987;  25 1014-1018
  • 74 Al Saigul A M, Fontaine R E, Haddad Q. Nosocomial malaria from contamination of a multidose heparin container with blood.  Infect Control Hosp Epidemiol. 2000;  21 329-330
  • 75 McHugh G J, Roper G M. Propofol emulsion and bacterial contamination.  Can J Anaesth. 1995;  42 801-804
  • 76 Tessler M, Dascal A, Gioseffini S, Miller M, Mendelson J. Growth curves of Staphylococcus aureus, Candida albicans, and Moraxella osloensis in propofol and other media.  Can J Anaesth. 1992;  39 509-511
  • 77 Obayashi A, Oie S, Kamiya A. Microbial viability in preparations packaged for single use.  Biol Pharm Bull. 2003;  26 667-670
  • 78 Aydin N, Aydin N, Gultekin B, Ozgun S, Gurel A. Bacterial contamination of propofol: the effects of temperature and lidocaine.  Eur J Anaesthesiol. 2002;  19 455-458
  • 79 Anding K, Daschner F. The growth of pathogenic germs in propofol.  Anaesthesist. 1992;  41 433-434
  • 80 Thomas D V. Propofol supports bacterial growth.  Br J Anaesth. 1991;  66 274
  • 81 Magee L, Godsiff L, Matthews I, Farrington M, Park G R. Anaesthetic drugs and bacterial contamination.  Eur J Anaesthesiol Suppl. 1995;  12 41-43
  • 82 Arnold B D, Bilski A J. Drawing up propofol.  Anaesthesia. 1994;  49 738-739
  • 83 Braun B. Rote Liste 2005. 
  • 84 Rowe W L. Economics and anaesthesia.  Anaesthesia. 1998;  53 782-788
  • 85 el Mikatti N, Dillon P, Healy T E. Hygienic practices of consultant anaesthetists: a survey in the north-west region of the UK.  Anaesthesia. 1999;  54 13-18
  • 86 Tait A R, Tuttle D B. Preventing perioperative transmission of infection: a survey of anesthesiology practice.  Anesth Analg. 1995;  80 764-769
  • 87 Sproat L J, Inglis T J. A multicentre survey of hand hygiene practice in intensive care units.  J Hosp Infect. 1994;  26 137-148
  • 88 Wise H J, McCormick R N. Re-enforcing hygiene practices of anaesthetists.  Anaesthesia. 1999;  54 1220-1221
  • 89 CDC . Postsurgical infections associated with an extrinsically contaminated intravenous anesthetic agent - California, Illinois, Maine, and Michigan, 1990.  MMWR Morb Mortal Wkly Rep. 1990;  39 426-427, 433
  • 90 Daily M J, Dickey J B, Packo K H. Endogenous Candida endophthalmitis after intravenous anesthesia with propofol.  Arch Ophthalmol. 1991;  109 1081-1084
  • 91 Villarino M E, McNeil M M, Hall W N. Postsurgical infections associated with an extrinsically contaminated intravenous anesthetic agent. 31st Interscience Conference on Antimicrobial Agents and Chemotherapy.  Chicago. 1999;  156 346
  • 92 Veber B, Gachot B, Bedos J P, Wolff M. Severe sepsis after intravenous injection of contaminated propofol.  Anesthesiology. 1994;  80 712-713
  • 93 Bennett S N, McNeil M M, Bland L A. et al . Postoperative infections traced to contamination of an intravenous anesthetic, propofol.  N Engl J Med. 1995;  333 147-154
  • 94 Kuehnert M J, Webb R M, Jochimsen E M. et al . Staphylococcus aureus bloodstream infections among patients undergoing electroconvulsive therapy traced to breaks in infection control and possible extrinsic contamination by propofol.  Anesth Analg. 1997;  85 420-425
  • 95 Henry B, Plante-Jenkins C, Ostrowska K. An outbreak of Serratia marcescens associated with the anesthetic agent propofol.  Am J Infect Control. 2001;  29 312-315
  • 96 Massari M, Petrosillo N, Ippolito G. et al . Transmission of hepatitis C virus in a gynecological surgery setting.  J Clin Microbiol. 2001;  39 2860-2863
  • 97 Weist K, Wilbrandt B, Herm T, Halle E, Melzer C, Ruden H. Severe cases of sepsis in an outpatient clnic caused by contaminated intravenous propofol. 2002. Wissenschaftliches Programm der 54. DGHM-Tagung, Heidelberg,. 6. - 10. Oktober 2002
  • 98 Tallis G F, Ryan G M, Lambert S B. et al . Evidence of patient-to-patient transmission of hepatitis C virus through contaminated intravenous anaesthetic ampoules.  J Viral Hepat. 2003;  10 234-239

Dr. med. Ralf-Peter Vonberg

Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover

Carl-Neuberg-Straße 1 · 30625 Hannover

Email: Vonberg.Ralf@MH-Hannover.de

    >