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Synthesis 2005(16): 2713-2717  
DOI: 10.1055/s-2005-872099
PAPER
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Facile One-Step Carbamoylation of 6-Aminouracils

Ill Young Lee*, Jin Young Lee, Young-Dae Gong*
The Center for High Throughput Synthesis Platform Technology, Korea Research Institute of Chemical Technology, P.O. Box 107, Yusong, Taejon 305-600, Korea
Fax: +82(42)8611291; e-Mail: iylee@krict.re.kr;
Further Information

Publication History

Received 4 April 2005
Publication Date:
25 July 2005 (online)

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Abstract

Carbamoylation of 6-aminouracils was achieved by reacting 6-aminouracils with isocyanates under computer-controlled microwave irradiation for a short reaction time. Under known thermal conditions, most of carbamoylated uracils are obtained in poor yields with long reaction times.

Key words

microwave - 6-aminouracil - isocyanates - heterocycles - carbamoylation

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