Download PDF
Synfacts 2005(2): 0187-0187  
DOI: 10.1055/s-2005-916043
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Interiotherin A and Gomisin R

Contributor(s): Philip Kocienski, Fiona Black
R. S. Coleman*, S. R. Gurrala
The Ohio State University, Columbus, USA
Further Information

Publication History

Publication Date:
25 October 2005 (online)

    Permissions and Reprints

Significance

Many dibenzocyclooctadiene lignans have been isolated from the Schisandraceae family of plants and several of these show interesting biological activities. Interiotherin A, isolated from the vine Kadsura interior, inhibits the replication of HIV. Angeloylgomisin R is a closely related analogue of Interiotherin A.