Synthesis of (-)-Kendomycin

A. B. Smith; E. F. Mesaros; E. A. Meyer

doi:10.1055/s-2005-916055

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Synfacts 2005(2): 0190-0190
DOI: 10.1055/s-2005-916055

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Kendomycin

Contributor(s): Philip Kocienski
III, A. B. Smith*, E. F. Mesaros, E. A. Meyer
University Of Pennsylvania, Philadelphia, USA

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Publication History

Publication Date:
25 October 2005 (online)

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Significance

The target molecule (isolated from Streptomyces violaceoruber) is an endothelin receptor antagonist and antiosteoporotic agent. It is also active against multiresistant bacteria, including vancomycin-resistant strains.