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Synfacts 2005(3): 0321-0321
DOI: 10.1055/s-2005-916127
DOI: 10.1055/s-2005-916127
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Ti(IV)-Catalyzed Asymmetric Nitrone Cycloaddition
T. Kano, T. Hashimoto, K. Maruoka*
Kyoto University, Japan
Further Information
Publication History
Publication Date:
22 November 2005 (online)
Significance
The asymmetric 1,3-dipolar cycloaddition of nitrones and enals has recently received attention as a short route to useful chiral building blocks. Using an oxo-bridged dinuclear Ti(IV) catalyst, a variety of nitrones provided chiral isoxazolidines of good to excellent enantiomeric excess upon reaction with acrolein.