Synthesis of ent-Halimanolides from ent-Halimic Acid

I. S. Marcos; A. B. Pedrero; M. J. Sexmero; D. Diez; N. García; M. A. Escola; P. Basabe; A. Conde; R. F. Moro; J. G. Urones

doi:10.1055/s-2005-918475

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Synthesis 2005(19): 3301-3310
DOI: 10.1055/s-2005-918475

PAPER

Synthesis of ent-Halimanolides from ent-Halimic Acid

I. S. Marcos*, A. B. Pedrero, M. J. Sexmero, D. Diez, N. García, M. A. Escola, P. Basabe, A. Conde, R. F. Moro, J. G. Urones
Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, 37008 Salamanca, Spain
Fax: +34(923)294574; e-Mail: ismarcos@usal.es;

Further Information

Publication History

Received 1 August 2005
Publication Date:
14 November 2005 (online)

Abstract
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Abstract

Three natural ent-halimanolides have been synthesized from ent-halimic acid. Their structures have been confirmed as well as their absolute configurations established. Bestmann methodology has been used for the synthesis of butenolides and for the synthesis of γ-hydroxybutenolides the Boukouvalas method has been employed.

Key words

diterpenes - alkaloids - ent-halimanolides - reduction

References

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