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Synthesis 2006(2): 279-284
DOI: 10.1055/s-2005-918514
DOI: 10.1055/s-2005-918514
PAPER
© Georg Thieme Verlag Stuttgart · New York
Reduction of 1-Nitrospiro[2.2]pentanecarboxylates: Convenient Synthesis of Novel Polyspirocyclic Cyclopropane Amino Acids
Further Information
Received
27 May 2005
Publication Date:
21 December 2005 (online)
Publication History
Publication Date:
21 December 2005 (online)
Abstract
A facile method for the preparation of a series of racemic spiropentane amino acids is described. An approach involving sequential catalytic cyclopropanation of polycyclic methylenecyclopropanes with nitrodiazoesters and reduction of the nitro group is described.
Key words
[1+2] cycloaddition - reductions - spiropentane α-amino acids - carbenes/diazo compounds
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