Squamous-cell carcinoma of the duodenum as a rare cause of upper gastrointestinal bleeding

Endoscopy_UCTN_Code_CCL_1AB_2AZ_3AB

Figure 1 A 75-year-old woman was admitted with upper gastrointestinal bleeding. Endoscopic examination showed an ulcerated tumor in the posterior part of the duodenal bulb, with infiltration of the pylorus and an impression of the posterior gastric wall (Video 1).

Figure 2 Helical computed tomography scan of the abdomen with coronal reconstructions, confirmed a malignancy in the duodenum with encroachment on the pylorus and infiltration of the surroundings.

Figure 3 Hematoxylin-eosin stained sections of duodenal biopsies revealed typical squamous-cell carcinoma with large, eosinophilic cells with distinct cell borders, keratinization, and formation of small horn pearls. Primary squamous-cell carcinoma of the duodenum is very rare. To date, mostly duodenal metastases from squamous-cell carcinoma originating from a different primary site have been reported.

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