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Synthesis 2006(6): 949-951  
DOI: 10.1055/s-2006-926359
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Simple Method for the Preparation of Glycosyl Isothiocyanates

Marco Kühnea, Zoltán Györgydeákb, Thisbe K. Lindhorst*a
a Otto-Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel, Otto-Hahn-Platz 3, 24098 Kiel, Germany
Fax: +49(431)8807410; e-Mail: tklind@oc.uni-kiel.de;
b Department of Organic Chemistry, University of Debrecen, P.O. Box 20, 4010 Debrecen, Hungary
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Publication History

Received 26 August 2005
Publication Date:
27 February 2006 (online)

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Abstract

Glycosyl isothiocyanates became accessible from the corresponding peracetylated sugars in one step, by application of trimethylsilyl isothiocyanate and a Lewis acid in dichloromethane at room temperature.

Key words

carbohydrates - isothiocyanates - disaccharides - anomeric purity - glycomimetics