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Semin Neurol 2006; 26(4): 387-395
DOI: 10.1055/s-2006-948319
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Therapeutic Hypothermia for Brain Injury after Cardiac Arrest

Fred Rincon1 , Stephan A. Mayer1 , 2
  • 1Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology, Columbia University, New York, New York
  • 2Department of Neurosurgery, College of Physicians and Surgeons, Columbia University, New York, New York
Further Information

Publication History

Publication Date:
10 August 2006 (online)

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ABSTRACT

Morbidity and mortality in patients successfully resuscitated from cardiac arrest primarily depends on neurological outcome. Clinical trials of therapies directed toward reducing the extent of neuronal damage by means of pharmacological agents have been disappointing. To date, the only clinically effective tool for amelioration of brain damage by ischemia and reperfusion is mild to moderate induced hypothermia. The pathophysiology of global hypoxic-ischemic brain injury, the mechanisms by which hypothermia confers neuroprotection, and the encouraging beneficial effects of mild to moderate hypothermia in experimental studies and clinical trials are discussed.

KEYWORDS

Ventricular fibrillation - asystole - reperfusion injury

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Stephan A MayerM.D. 

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