Synthesis of M58163 and M58169

F. Saitoh; H. Nishida; T. Mukaihira; K. Aikawa; K. Mikami

doi:10.1055/s-2007-958286

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Synfacts 2007(4): 0341-0341
DOI: 10.1055/s-2007-958286

Synthesis of Natural Products and Potential Drugs

Synthesis of M58163 and M58169

Contributor(s): Philip Kocienski
F. Saitoh*, H. Nishida, T. Mukaihira, K. Aikawa, K. Mikami*
Tokyo Institute of Technology and Mochida Pharmaceutical Co., Ltd., Shizuoka, Japan

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Publication History

Publication Date:
23 March 2007 (online)

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Significance

M58163 and M58169 are being developed for the prevention of thrombosis because they inhibit Factor X_a, an enzyme implicated in the coagulation cascade. The key step entails a dynamic kinetic resolution in the La-catalyzed amide formation leading to E.