Download PDF
Endoscopy 2007; 39(11): 969-973
DOI: 10.1055/s-2007-966924
DDW Highlights

© Georg Thieme Verlag KG Stuttgart · New York

Reflux disease and Barrett’s esophagus

H.  Louis1
  • 1Department of Gastroenterology and Hepatopancreatology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium
Further Information

Publication History

Publication Date:
10 October 2007 (online)

Also available at
    Permissions and Reprints

Introduction

Several novel diagnostic methods have been developed for the diagnosis of gastroesophageal reflux disease (GERD) over the past few years, aiming either to be more convenient for patients, or to increase our diagnostic capabilities. In the same way, novel enhanced endoscopic imaging techniques have now become widely available, but the place of these new tools in clinical practice is still to be defined. The detection and treatment of early cancer in patients diagnosed with Barrett’s esophagus remains a challenge. This year in Washington, several abstracts at Digestive Disease Week presented novel techniques in the field of GERD and Barrett’s esophagus.

  • 1 Pandolfino J E, El Serag H B, Zhang Q. et al . Obesity: a challenge to esophagogastric junction integrity.  Gastroenterology. 2006;  130 639-649
    CrossrefPubMedGoogle Scholar
  • 2 Wu J, Mui W L, Chan W. et al . Obesity is associated with increased transient lower esophageal sphincter relaxation.  Gastroenterology. 2007;  132 A121
    PubMedGoogle Scholar
  • 3 Beaumont H, de Jong J W, Bennink . et al . Scintigraphic imaging of esophageal shortening and the acid pocket in humans.  Gastroenterology. 2007;  132 A121
    PubMedGoogle Scholar
  • 4 Schey R, Dickman R M, Parthasarathy S. et al . Sleep deprivation is hyperalgesic in patients with gastroesophageal reflux disease (GERD).  Gastroenterology. 2007;  132 A122
    PubMedGoogle Scholar
  • 5 Strugala V, McGlashan J A, Watson A G. et al . Evaluation of a non-invasive dipstick test for the diagnosis of extra-oesophageal reflux: results of a pilot study.  Gastroenterology. 2007;  132 A99
    PubMedGoogle Scholar
  • 6 Fiocca R, Fernström P, Franzen S. et al . Can pathologists agree in the assessment of microscopic esophagitis?.  Gastroenterology. 2007;  132 A281
    PubMedGoogle Scholar
  • 7 Kara M A, Peters F P, Rosmolen W D. et al . High-resolution endoscopy plus chromoendoscopy or narrow-band imaging in Barrett’s esophagus: a prospective randomized crossover study.  Endoscopy. 2005;  37 929-936
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Sharma P, Bansal A, Mathur S. et al . The utility of a novel narrow band imaging endoscopy system in patients with Barrett’s esophagus.  Gastrointest Endosc. 2006;  64 167-175
    CrossrefPubMedGoogle Scholar
  • 9 Sharma P, Wani S B, Rastogi A. et al . Effect of acid suppressive therapy on narrow-band imaging (NBI) findings in gastroesophageal reflux disease (GERD) patients.  Gastroenterology. 2007;  132 A98
    PubMedGoogle Scholar
  • 10 Fox M R, Canavan R, Anggiansah A. et al . What is the optimal duration of oesophageal pH measurement and symptom assessment? A prospective study using 96-hr BRAVO recordings.  Gastroenterology. 2007;  132 A99
    PubMedGoogle Scholar
  • 11 Gilles M D, Ayers G D, Vaezi M F. 96 hours no better than 24 hours in atypical GERD.  Gastroenterology. 2007;  132 A99
    PubMedGoogle Scholar
  • 12 Zerbib F, Roman S, Ropert A. et al . Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy.  Am J Gastroenterol. 2006;  101 1956-1963
    CrossrefPubMedGoogle Scholar
  • 13 Zentilin P, Della Casa D, Fanucchi M. et al . 24-hour ambulatory intraluminal pH-impedance in patients with non-erosive reflux disease (NERD).  Gastroenterology. 2007;  132 A140
    PubMedGoogle Scholar
  • 14 Wu J, Ching J, Au K. et al . Clinical course of patients with non-erosive gastroeophageal reflux disease (NERD) on step-down acid suppressive therapy: a prospective cohort study.  Gastroenterology. 2007;  132 A139
    CrossrefPubMedGoogle Scholar
  • 15 Iuga L M, Orvidas L J, Dierkhising R A. et al . Which supraesophageal reflux symptoms reliably respond to PPI therapy? Results from a randomized, double-blind, placebo-controlled trial (RCT).  Gastroenterology. 2007;  132 A99
    PubMedGoogle Scholar
  • 16 Lundell L R, Miettinen P, Myrvold H E. et al . Anti-reflux surgery compared with maintenance omeprazole for reflux esophagitis: results after 12 years.  Gastroenterology. 2007;  132 A107
    PubMedGoogle Scholar
  • 17 Targownik L E, Laheij R J, Metge C. et al . Proton pump inhibitor use is associated with an increased risk of severe community-acquired infections.  Gastroenterology. 2007;  132 A189
    PubMedGoogle Scholar
  • 18 Estborn L, Joelson S. Respiratory tract infections with acid-suppressive therapy: a retrospective analysis of 31 comparative clinical studies in esomeprazole.  Gastroenterology. 2007;  132 A159
    PubMedGoogle Scholar
  • 19 Falk G W, Fennerty M B, Rothstein R I. AGA Institute technical review on the use of endoscopic therapy for gastroesophageal reflux disease.  Gastroenterology. 2006;  131 1315-1336
    CrossrefPubMedGoogle Scholar
  • 20 Pleskow D, Rothstein R, Kozarek R. et al . Endoscopic full-thickness plication for the treatment of GERD: long-term multicenter results.  Surg Endosc. 2007;  21 439-444
    CrossrefPubMedGoogle Scholar
  • 21 Dundon J M, Davis S, Hazey J W. et al . Radiofrequency energy delivery to the lower esophageal sphincter (Stretta) does not provide long-term symptom control.  Gastrointest Endosc. 2007;  65 AB129
    PubMedGoogle Scholar
  • 22 Kuan-Hao C, Mukaisho K I, Araki Y. et al . High fat intake plays a crucial role in the development of Barrett’s esophagus and esophageal adenocarcinoma through elevated bile acids in duodenal contents reflux.  Gastroenterology. 2007;  132 A260
    PubMedGoogle Scholar
  • 23 Menke V, Capello A, Kusters J G. et al . Th1 immune status in patients is associated with an increased risk for Barrett’s esophagus.  Gastroenterology. 2007;  132 A76
    CrossrefPubMedGoogle Scholar
  • 24 Razvi M, Dar A, Washington K. et al . Transcriptional hotspots in Barrett’s-related adenocarcinomas.  Gastroenterology. 2007;  132 A133
    PubMedGoogle Scholar
  • 25 Buttar N, DeMars C, Madhavan M. et al . Role of KLF in neoplastic progression in Barrett’s esophagus.  Gastroenterology. 2007;  132 A76
    CrossrefPubMedGoogle Scholar
  • 26 Wong A, Lovat L L, Burnham R. et al . Large-scale prospective study reveals novel risk factors for Barrett’s oesophagus.  Gastroenterology. 2007;  132 A254
    PubMedGoogle Scholar
  • 27 Modiano N, Shahnia S, Gerson L B. Development of Barrett’s esophagus after erosive esophagitis.  Gastrointest Endosc. 2007;  65 AB142
    PubMedGoogle Scholar
  • 28 Meining A, Pohl H, Becker V. et al . Miniprobe-based confocal fluorescence microscopy for detection of focal malignancy in Barrett’s esophagus.  Gastrointest Endosc. 2007;  65 AB138
    PubMedGoogle Scholar
  • 29 Meining A, Saur D, Bajbouj M. et al . Real-time in-vivo histopathology for detection of neoplasia using a portable, confocal miniprobe: a blinded analysis.  Gastroenterology. 2007;  132 A97
    PubMedGoogle Scholar
  • 30 Gatenby P A, Ramus J A, Caygill C P. et al . The outcome of low-grade dysplasia in Barrett’s columnar-lined esophagus: a large cohort study from the UK national Barrett’s oesophagus registry.  Gastrointest Endosc. 2007;  65 AB133
    PubMedGoogle Scholar
  • 31 Mackenzie G, Yong M, Clark B. et al . Elastic scattering spectroscopy to generate an image of patient risk in Barrett’s esophagus.  Gastroenterology. 2007;  132 A96
    CrossrefPubMedGoogle Scholar
  • 32 Pech O, Manner H, Petrone M C. et al . One-step chromoendoscopy and structure enhancement using balsamic vinegar for screening of Barrett’s esophagus.  Gastrointest Endosc. 2007;  65 AB146
    PubMedGoogle Scholar
  • 33 Kiesslich R, Hoffman A, Vieth M. et al . 80 mg esomeprazole daily over 6 months does not lead to a significant regression of Barrett’s esophagus: results from a prospective randomized trial.  Gastrointest Endosc. 2007;  65 AB151
    PubMedGoogle Scholar
  • 34 Pech O, Behrens A, Nachbar L. et al . Long-term results and risk factor analysis for recurrence in 349 patients with high-grade dysplasia and mucosal adenocarcinoma in Barrett’s esophagus.  Gastrointest Endosc. 2007;  65 AB99
    PubMedGoogle Scholar
  • 35 Manner H, May A, Pech O. et al . Early Barrett’s carcinoma with minimal submucosal involvement: long-term results of endoscopic resection with a curative intent.  Gastrointest Endosc. 2007;  65 AB136
    PubMedGoogle Scholar
  • 36 Wang K K, Buttar N, Prasad G A. et al . Endoscopic mucosal resection in Barrett’s esophagus: predictors of success and complications.  Gastroenterology. 2007;  132 A64
    PubMedGoogle Scholar
  • 37 Prasad G A, Wang K K, Halling K C. et al . Biomarkers in the therapy of Barrett’s esophagus with high-grade dysplasia.  Gastroenterology. 2007;  132 A64
    PubMedGoogle Scholar
  • 38 Pouw R E, Gondrie J J, Sondermeijer C. et al . Novel combined therapy for Barrett’s esophagus containing high-grade dysplasia: endoscopic mucosal resection followed by circumferential and focal ablation using the HALO system.  Gastrointest Endosc. 2007;  65 AB111
    PubMedGoogle Scholar
  • 39 Hernandez J C, Tsai F, Reicher S. et al . Frequency of buried Barrett’s metaplasia after BÂRRX ablation for intestinal metaplasia with or without dysplasia.  Gastrointest Endosc. 2007;  65 AB111
    PubMedGoogle Scholar
  • 40 Mashimo H, Chen Y, Huang S W. et al . Endoscopic coherence tomography reveals Barrett’s underneath squamous neo-epithlium after radiofrequency ablation.  Gastroenterology. 2007;  132 A96
    CrossrefPubMedGoogle Scholar
  • 41 Dumot J A, Vargo J J, Zuccaro G. et al . Preliminary results of cryotherapy ablation for esophageal high-grade dysplasia (HGD) or intra-mucosal cancer (IMC) in high-risk non-surgical patients.  Gastrointest Endosc. 2007;  65 AB110
    PubMedGoogle Scholar

H. Louis, MD, PhD

Department of Gastroenterology and Hepatopancreatology

Erasme Hospital

Route de Lennik 808

B-1070 Brussels

Belgium

Fax: +32-2-555-46-97

Email: hlouis@ulb.ac.be

      >