Lanthanide-Pybox Catalyzed Mukaiyama Aldol Reaction

Significance

In the further development of the Mukiayama aldol reaction catalyzed by box and pybox ligands originally pioneered by Evans, led the authors to find an alternative ligand-metal system to optimize enantioselectivity and yields. The authors studied lanthanide pybox complexes and demonstrate high yields and selectivities using scandium and lutetium.