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Synfacts 2007(5): 0501-0501  
DOI: 10.1055/s-2007-968436
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rh(I)-Catalyzed Enantioselective Hydrosilylation-Cyclization

Contributor(s): Mark Lautens, Yann Béthuel
B.-M. Fan, J.-H. Xie, S. Li, L.-X. Wang, Q.-L. Zhou*
Nankai University, Tianjin, P. R. of China
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Publication History

Publication Date:
24 April 2007 (online)

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Significance

In the present paper, the authors examine the utility of their recently developed SDP ligand (Angew. Chem. Int. Ed. 2002, 41, 2348-2350) for the Rh-catalyzed asymmetric silylcyclization of 1,6-enynes. This nearly unexplored topic (for the only other report, see: H. Chakrapani, C. Liu, R. A. Widenhoefer Org Lett. 2003, 5, 157-159) allows for easy access to enantioenriched methylene pyrrolidines.