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Synfacts 2007(10): 1011-1011  
DOI: 10.1055/s-2007-968949
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Platensimycin

Contributor(s): Philip Kocienski, Zofia Komsta
K. C. Nicolaou*, D. J. Edmonds, A. Li, G. S. Tria
The Scripps Research Institute and University of California at San Diego, La Jolla, USA
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Publication History

Publication Date:
07 November 2007 (online)

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Significance

(-)-Platensimycin has potential for the treatment of drug-resistant bacterial infections. Nicolaou and co-workers reported two asymmetric total syntheses complementing the previously described racemic version: K. C. Nicolaou, A. Li, D. J. Edmonds Angew. Chem. Int. Ed. 2007, 45, 7086.