Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice

Nobuhisa Ezaki; Masahide Kato; Nobuo Takizawa; Satoshi Morimoto; Gen-ichiro Nonaka; Itsuo Nishioka

doi:10.1055/s-2007-969386

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Planta Med 1985; 51(1): 34-38
DOI: 10.1055/s-2007-969386

Research Articles

Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice

Nobuhisa Ezaki¹ ^, ³ , Masahide Kato¹ , Nobuo Takizawa¹ , Satoshi Morimoto² , Gen-ichiro Nonaka² , Itsuo Nishioka²

¹Central Research Laboratories, Yomeishu Seize Co. Ltd.
²Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
³Nobuhisa Ezaki, Central Research Laboratories, Yomeishu Seizo Co. Ltd., 2132-37 Nakaminowa, Minowamachi, Kamiina-gun, Nagano, 399-46, Japan

* Part III, see reference(1)

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Publication History

1984

1984

Publication Date:
26 February 2007 (online)

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Abstract

Nine condensed tannin related compounds isolated from Linderae umbellatae Ramus, (+)-catechin (1), (-)-epicatechin (2), proanthocyanidin B-1 (3), B-2 (4), B-4 (5), trimer A (6), trimer B (7), cinnamtannin B₁ (8) and cinnamtannin D₁ (9), were tested for their effects on peptic activity and stress-induced gastric lesions in mice. Peptic activity of rat gastric juice was suppressed by 6 and 7 in vitro, and slightly suppressed by 8 and 9. In pylorus-ligated mice, these compounds, except for 4, administered orally exhibited anti-peptic activity. Pretreatments of 4,6 and 7 orally protected mice against stress-induced gastric lesions. Effects of these compounds on digestive systems were dìscussed.

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