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Planta Med 1985; 51(6): 494-498
DOI: 10.1055/s-2007-969573
DOI: 10.1055/s-2007-969573
Research Articles
© Georg Thieme Verlag Stuttgart · New York
Prenylated Phenolics that Cause Contact Dermatitis from Glandular Trichomes of Turricula parryi
Further Information
Publication History
1985
1985
Publication Date:
26 February 2007 (online)
Abstract
The principal phenolic constituents were isolated from the exudate of the glandular trichomes of Turricula parryi, a California shrub that causes severe contact dermatitis. The phenolic constituents consist of a complex mixture of methoxylated flavones and derivatives of both farnesylhydroquinone and 3-farnesyl-p-hydroxybenzoic acid in which the C-7 methyl of farnesyl is replaced by hydroxymethyl, formyl and carboxyl groups. Elicitors of allergic contact dermatitis were identified with guinea pigs sensitized to the crude exudate. The principal agents of dermatitis were the farnesyihydroquinone derivatives 3 and 6.