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Planta Med 1981; 43(10): 153-160
DOI: 10.1055/s-2007-971492
Research Articles

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Transformation of Alkaloids of the Colchicine Type in Leaves and Flowers of Colchicum autumnale and C. byzantinum

A Simplified Isolation Procedure1,2 F. Šantavý, VI. Preininger, V. Šimánek, H. Potěšilová
  • Institute of Chemistry, Medical Faculty, Palacký University, Olomouc, ČSSR
1 This paper constitutes Pan LXXXVIII on Isolation and Chemistry of Alkaloids from Plants of the Subfamily Wurmbaeoideae. Part LXXXVII: Acta Univ. Olomuc., Fac. Med. (Olomouc) 99, 115(1981).2 Dedicated to the Sixtieth Birthday of Prof. Dr. H. Oelschläger, Frankfurt a./Main
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Publication Date:
30 March 2007 (online)

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Abstract

It was found that the so far described variations in the content of colchicine alkaloids in leaves and flowers of Colchicum autumnale L. and C. byzantinum Ten. are due to enzymatic O-demethylation and degradation of colchicine (I), N-deacetyl-N-formylcolchicine (XI), and demecolcine (XVII) during drying and storing of the plant material. A simplified method was elaborated to separate the neutral, phenolic, basic, and basic-phenolic fractions of tropolone alkaloids.

Key Word Index

Colchicum autumnale - Colchicum byzantinum - Liliaceae - Colchicine Alkaloids - Enzymatic Degradation - Simplified Separation

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