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Horm Metab Res 1996; 28(11): 592-594
DOI: 10.1055/s-2007-979859
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

The Influence of Estrogens, Progesterone and their Antagonists on the Collagen Content in the Pregnant Rat Uterus

A. Bieńkiewicz, J. Welfel, Ewa Kuś
  • Institute of Gynecology and Obstetrics, Department of Pathophysiology, Medical University of łódź, łódź, Poland
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Publication History

1995

1996

Publication Date:
23 April 2007 (online)

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Abstract

The influence of progesterone, estrogens and their antagonists: mifepristone and tamoxifen on connective tissue metabolism in pregnant rat uterus near term was evaluated. Total collagen and its soluble fraction as well as water concentration was measured in a population of 65 pregnant rats; treated with progesterone (n = 10), mifepristone (n = 13), estradiol (n = 17) and tamoxifen (n = 12). The results suggest the important influence of sex steroids on the uterine connective tissue metabolism during pregnancy.

Key words

Uterus - Collagen - Progesterone - Mifepristone - Estradiol - Tamoxifen

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