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Synthesis 2007(12): 1765-1767  
DOI: 10.1055/s-2007-983710
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

An Approach to Amino Ester Subunits of Tamiflu

George A. Kraus*, Tinopiwa Goronga
Department of Chemistry, Iowa State University, Ames, IA 50011, USA
Fax: +515(294)0105; e-Mail: gakraus@iastate.edu;
Further Information

Publication History

Received 30 March 2007
Publication Date:
08 June 2007 (online)

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Abstract

A two-step synthesis of amino cyclohexene carboxylic acid esters has been achieved in good overall yield from nitro phosphonate and unsaturated aldehydes.

Key words

Tamiflu - Michael addition - ring closure

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