Download PDF
Synfacts 2007(11): 1123-1123  
DOI: 10.1055/s-2007-991207
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Dibromophakellstatin

Contributor(s): Philip Kocienski, Zofia Komsta
J. Lu, X. Tan, C. Chen*
The University of Texas Southwestern Medical Center at Dallas, USA
Further Information

Publication History

Publication Date:
23 October 2007 (online)

    Permissions and Reprints

Significance

(-)-Dibromophakellstatin is a pyrrole-imidazole alkaloid isolated from marine sponge Phakellia mauritiana that possesses remarkable cytotoxicity. The focal step of the very concise and high-yielding synthesis of racemic dibromophakellstatin is a palladium-mediated direct vinylation of imidazoline A. For an enantioselective synthesis, see: K. G. Poullennec, D. Romo J. Am. Chem. Soc. 2003, 125, 6344.