Phosphinated Polymer-Incarcerated Palladium Catalysts

Significance

Phosphinated polymer-incarcerated palladium (PI-Pd) catalysts were developed by encapsulating of Pd(PPh₃)₄ in polymeric phosphine ligands and cross-linking of the polymers (eq. 1). The catalysts were applied to the Suzuki-Miyaura reaction of aryl bromides with arylboronic acids (eq. 2), the amination of aryl halides (eq. 3), and the Sonogashira reaction of phenyl iodide with phenyl acetylene (eq. 4) to give the corresponding products in 0-100% yield. Catalyst 2a was reused for the Suzuki-Miyaura reaction without loss of catalytic acitivity while 2b was reused for the amination with a slight loss of catalytic acitivity.