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Synfacts 2007(11): 1177-1177  
DOI: 10.1055/s-2007-991256
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Nickel-Catalyzed Fluorination of Aryl Acetic Acid Derivatives

Contributor(s): Mark Lautens, Michael Langer
T. Suzuki, Y. Hamashima, M. Sodeoka*
RIKEN, Wako, Japan
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

The asymmetric fluorination of β-keto carbonyl compounds has attracted interest due to the enhanced pharmaceutical activity of F-containing compounds. Here, the enantioselective electrophilic fluorination of aryl acetic acid derivatives is reported and can afford after cleavage of the thiooxazolidinone moiety chiral α-mono­fluorinated carboxylic acids without loss of stereo­chemical information (see reviews below).