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Synfacts 2007(12): 1239-1239
DOI: 10.1055/s-2007-991406
DOI: 10.1055/s-2007-991406
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
Copper-Catalyzed α-Enolate Arylation Route to 2,3-Disubstituted Indoles
S. Tanimori*, H. Ura, M. Kirihata
Osaka Prefecture University, Japan
Further Information
Publication History
Publication Date:
22 November 2007 (online)
Significance
A one-step synthesis of 2,3-disubstituted indoles via Cu-catalyzed α-arylation-cyclization of 2-iodoaniline with β-keto esters is described. This reaction proceeds smoothly under mild conditions in modest to excellent yields. 2-Aryl-, -heteroaryl-, and -monoterpenoid-substituted indoles were prepared. However, the scope and limitations of the iodoaniline coupling partner were not well investigated.