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Synfacts 2008(2): 0157-0157  
DOI: 10.1055/s-2007-992442
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rhodium-Catalyzed Hydrogenation with Phosphine-Phosphoramidite Ligands

Contributor(s): Hisashi Yamamoto, Joshua N. Payette
D.-Y. Wang, X.-P. Hu*, J.-D. Huang, J. Deng, S.-B. Yu, Z.-C. Duan, X.-F. Xu, Z. Zheng
Dalian Institute of Chemical Physics and Graduate School of Chinese Academy of Sciences, Beijing, P. R. of China
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Publication History

Publication Date:
23 January 2008 (online)

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Significance

The authors report a highly enantio­selective hydrogenation of β-aryl-, β-alkoxy-, and β-alkyl-substituted enol ester phosphonates. All substrates gave uniformly excellent yields and enantioselectivities. This work represents a significant advance over previously reported methods with regard to enantioselectivity and substrate scope (Chem. Commun. 2005, 628). The authors attribute the high levels of asymmetric induction to the use of the rigid unsymmetrical hybrid bidentate phosphorus ligand L1.