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Synfacts 2008(2): 0166-0166  
DOI: 10.1055/s-2007-992453
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Synthesis of P-Chiral Phosphine Ligands with Alkynyl Groups

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
T. Imamoto*, Y. Saitoh, A. Koide, T. Ogura, K. Yoshida
Chiba University, Japan
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Publication History

Publication Date:
23 January 2008 (online)

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Significance

Many years ago, Imamoto and co-workers discovered stable P-B complexes and used them to synthesize various chiral phosphines. Here he reports the synthesis of P-chiral phosphines containing alkynyl groups. The procedure offers a variety of chiral phosphines, many of which succeeded as ligands in asymmetric reactions such as hydrogenation, conjugate addition and an alkylative ring-opening reaction.