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Synfacts 2008(2): 0208-0208  
DOI: 10.1055/s-2007-992520
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

One-Pot Preparation of a Fragrance with a Palladium Catalyst

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada
M. J. Climent, A. Corma*, S. Iborra, M. Mifsud
Universidad Politecnica de Valencia, Spain
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Publication History

Publication Date:
23 January 2008 (online)

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Significance

A one-pot preparation of a fragrance [4-(p-methoxyphenyl)butan-2-one, 3] was reported via the heterogeneous Heck and hydrogenation reactions. Thus, the Heck reaction of 1 and methyl vinyl ketone was performed in an autoclave with a heterogeneous Pd catalyst [2 wt% on TiO2 (2Pd-TiO2)] and Na2CO3 to give 2 in 100% yield. The one-pot hydrogenation of 2 was carried out with H2 gas to give 3 with 97% yield. The cata­lyst was reused without a significant loss of catalytic acitivity.