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Horm Metab Res 1980; 12(1): 31-34
DOI: 10.1055/s-2007-996190
© Georg Thieme Verlag, Stuttgart · New York

Stimulatory Effects of Gamma-Aminohydroxybutyric Acid (GABOB) on Growth Hormone, Prolactin and Cortisol Release in Man

J. Takahara, S. Yunoki, W. Yakushiji, J. Yamauchi, H. Hosogi, T. Ofuji
  • Third Department of Internal Medicine, Okayama University School of Medicine, Okayama, Japan
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Publication History

1979

1979

Publication Date:
22 April 2008 (online)

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Summary

Healthy male volunteers injected subcutaneously with 200 mg L-GABOB showed no significant changes in plasma GH, prolactin and cortisol levels. On the other hand, an intrathecal injection of 300 mg D, L-GABOB to cerebrovascular patients caused significant increases in plasma GH, prolactin and cortisol levels at 60 min after injection. These results indicate that GABOB may elicit the secretion of GH, prolactin and ACTH via the central nervous system.

Key-Words

GABOB - GH - Prolactin - Cortisol - Human Subjects

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