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Horm Metab Res 1980; 12(2): 80-83
DOI: 10.1055/s-2007-996206
© Georg Thieme Verlag, Stuttgart · New York

Changes in Plasma Cyclic Nucleotides Levels during Various Acute Physical Stresses

F. Okada1 , M. Honma2 , M. Ui2
  • 1Health Administration Center, Department of Psychiatry and Neurology, School of Medicine
  • 2Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporc, Japan
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Publication History

1979

1979

Publication Date:
14 March 2008 (online)

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Summary

Studies were performed with healthy volunteers to determine the effects of various stresses known to increase sympathetic nerve activity on the plasma concentration of cyclic AMP and cyclic GMP.

Plasma cyclic AMP rose promptly in response to exercise; the elevation was completely abolished by a simultaneous injection of propranolol. Plasma cyclic GMP rose slightly after exercise; the elevation was completely abolished by a simultaneous injection of atropine. No significant changes occurred during tilting and cold pressor stress.

The increase in plasma concentrations of cyclic AMP and cyclic GMP may serve as putative indices for β-adrenergic, and cholinergic functions respectively during excercise of humans.

Key-Words

Tilting - Cold Pressor Stress - Exercise - Plasma cAMP - Plasma cGMP - Propranolol - Atropine

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