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Horm Metab Res 1980; 12(12): 685-687
DOI: 10.1055/s-2007-999232
© Georg Thieme Verlag, Stuttgart · New York

Ipodate and 8-Anilino-1-Naphthalene Sulfonic Acid Block Receptor Binding of T3 in Rat Liver

K. D. Burman, Y. G. Lukes, K. R. Latham, L. Wartofsky
  • The Endocrine-Metabolism Service, The Kyle Metabolic Unit, Walter Reed Army Medical Center, Washington, and the Department of Medicine, Uniformed Services University of the Health Science, Bethesda, Maryland, U.S.A.
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Publication History

1980

1980

Publication Date:
22 April 2008 (online)

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Summary

We have determined that 8-anilino-l-naphthalene sulfonic acid (ANS) and ipodate are effective inhibitor in vitro of 125I-T3 binding to rat hepatic nuclei receptors. Both of these agents are estimated to have a Kd for the T3 receptor of about 1-2 × 10-4 M. Indirect preliminary studies suggest that ANS is a non-competitive inhibitor and ipodate is a competitive inhibitor of T3 binding. Compounds such as tyropanoate and diatrizoate and iodide had no effect on T3 receptor binding. Further in vivo studies with ipodate suggested that T3 receptor binding inhibition also occurred when ipodate was given intravenously to rats.

Key-Words

T 3 Receptor - 8-Anilino-l-Naphthalene Sulfonic Acid - Ipodate

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