Regio- and Stereoselective Synthesis of 1,4-Dienes

F. Kolundzic; G. C. Micalizio

doi:10.1055/s-2008-1042735

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Synfacts 2008(3): 0301-0301
DOI: 10.1055/s-2008-1042735

Metal-Mediated Synthesis

Regio- and Stereoselective Synthesis of 1,4-Dienes

Contributor(s): Paul Knochel, Tobias Thaler
F. Kolundzic, G. C. Micalizio*
Yale University, New Haven, USA

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Publication History

Publication Date:
21 February 2008 (online)

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Significance

A new stereo- and regioselective cross-coupling reaction between allylic alcohols and alkynes is described. The method is general and can be applied to primary, secondary, and tertiary allylic alcohols yielding 1,4-dienes with various substitution patterns.