Mixed Lithium-Zinc Species for the Deprotonation of Five-Membered Aromatic Heterocycles

J.-M. L’Helgoual’ch; A. Seggio; F. Chevallier; M. Yonehara; E. Jeanneau; M. Uchiyama; F. Mongin

doi:10.1055/s-2008-1042738

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Synfacts 2008(3): 0304-0304
DOI: 10.1055/s-2008-1042738

Metal-Mediated Synthesis

Mixed Lithium-Zinc Species for the Deprotonation of Five-Membered Aromatic Heterocycles

Contributor(s): Paul Knochel, Tobias Thaler
J.-M. L’Helgoual’ch, A. Seggio, F. Chevallier, M. Yonehara, E. Jeanneau, M. Uchiyama*, F. Mongin*
Université de Rennes 1 and Université Claude Bernard Lyon 1, Villeurbanne, France; RIKEN, Wako-shi, Japan

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Publication History

Publication Date:
21 February 2008 (online)

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Significance

The article describes a novel synergetic approach towards the chemoselective deprotonation of five-membered heterocycles. Hereby, (TMP)₂Zn (0.5 equiv) and LiTMP (0.5 equiv) are prepared in situ from LiTMP and ZnCl₂ ^.TMEDA which are employed in a 3:1 ratio.