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Synfacts 2008(4): 0434-0434
DOI: 10.1055/s-2008-1042777
DOI: 10.1055/s-2008-1042777
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Suzuki-Miyaura Coupling Reaction in Water with a Polymer-Supported Palladium Catalyst
L. Bai, J.-X. Wang*
Northwest Normal University, Lanzhou; Lanzhou University and Lanzhou City University, P. R. of China
Further Information
Publication History
Publication Date:
19 March 2008 (online)
Significance
Polymer-supported phosphine-palladium complex 1 was found to promote the Suzuki-Miyaura cross-coupling reaction in water under microwave irradiation conditions. Thus, the polymer-supported catalyst 1 was prepared according to the reported procedures (L. Bai, Y. M. Zhang, J.-X. Wang QSAR Comb. Sci. 2004, 23, 857). The cross-coupling of 2-bromonaphthalene with sodium tetraphenylborate was carried out in the presence of the polymeric catalyst 1, K2CO3, and tetrabutylammonium bromide in water to give 2-phenylnaphthalene in 93% yield. The catalyst 1 was recovered and reused 10 times without any loss of activity (average 92% yields for 10 times).